Arizona · Nonprofit
CRITICAL PATH INSTITUTE
CRITICAL PATH INSTITUTE (Arizona) receives grants from 21 organizations whose IRS filings report $19,882,166 to it, the largest being GATES FOUNDATION ($6,977,608). 11 of them have funded it in more than one year.
- Revenue FY2025
- $47M
- Funders on record
- 21
- Grants received
- $20M
- Net assets
- $26M
What Critical Path Institute does
Mission
The Critical Path Institute is a catalyst in the development of new approaches that advance medical innovation and regulatory science. This is achieved by leading teams that share data, knowledge and expertise resulting in sound, consensus based science.
As stated on its FY2025 Form 990.
Programs
Critical path for rare neurodegenerative diseases (cp-rnd) - see schedule o
$6,720,599 spent21% of program spendingRare disease cures accelerator-data and analytics platform (rdca-dap) - see schedule o
$6,059,856 spentof which $1,319,385 as grants19% of program spendingCritical Path Institute's translational therapeutics accelerator (trxa) - see schedule o
$2,886,756 spentof which $1,612,597 as grants9% of program spendingCritical Path Institute also executes other projects and consortia in areas including therapeutics for the ataxias, polycystic kidney disorder, alzheimer's disease, parkinson's, tb, sickle cell disease, type 1 diabetes, duchenne muscular dystrophy, alpha-1 antitrypsin deficiency, lysosomal diseases, model informed drug development, patient-reported outcome, electronic clinical outcome assessment, rare disease clinical outcome assessment, transplant therapeutics, predictive safety testing, pediatrics, and others.
$15,684,004 spentof which $2,254,049 as grants$12,287,265 earned by the program50% of program spending
The 4 programs described on its FY2024 Form 990, listed largest first by expense. Program spending in total: $31,351,215.
The organization over time
Each line starts at 100 in 2017, so what you read is the shape rather than the size: 150 means half as much again as 2017, 50 means half. The number beside each label in the key is where it ended. The shaded band is where the middle 50% of its peers' revenue would sit, given their growth.
Balance sheet
Total assets and total liabilities at each year end, in dollars. The largest one-year move in total assets was 2024 to 2025, from $31M to $38M (+23%).
How it's funded, over time
Each bar is one year's revenue split into where it came from, and every bar is the same height — these are shares, not amounts, so a year that raised twice as much looks the same size. Hover a bar for the split.
Government-grant reliance: 2017 18% · 2018 23% · 2019 22% · 2020 39% · 2021 54% · 2022 54% · 2023 54% · 2024 54% · 2025 44%. Grants only. Government contracts and fees sit inside program revenue.
72% of CRITICAL PATH INSTITUTE’s revenue is contributions — more reliant on donations than three-quarters of its peers (7% for the typical peer).
Surplus & reserves
Operating surplus or deficit each year, and months of liquidity in hand. 0 of the last 9 reported years ran a deficit.
reserve
Leadership and staff
The officers, directors, trustees and key employees listed on each return. Joined and no longer listed compare each filing with the year before, matching people by surname and first initial; a year after a gap, or a roster under three people, has no comparison.
Board chair
Mr M Wainwright Fishburn Jr
Chairman
As listed on its FY2025 Form 990.
Who funds it, year by year
2017 → 2023: the base broadened from 5 funders to 7 funders, grant income fell $2.4M → $1.3M.
6 of 21 of your funders are donor-advised or pass-through sponsors (tagged DAF) — 10% of grant dollars received. That money is really individual donors directing a sponsor; the institutions to cultivate are the non-DAF funders.
From the IRS filings of CRITICAL PATH INSTITUTE’s funders (the co-funder graph). Association, not causation. Trends are read to FY2023, the last fiscal year that has finished arriving. FY2024–FY2026 are still being filed and are shown unshaded; they do not move any figure on this page.
How concentrated its funding is
CRITICAL PATH INSTITUTE leans on a few funders — its largest provides 35% of grant income and the top three 62%; half comes from just 2 funders.
the vertical line marks half of all grant income — 2 funders to its left
57% of the income these shares are computed over arrives through pass-through sponsors or from payers whose filings do not say what kind of payment it is. Concentration is still measured over all of it, because the money is real; what it does not support is a claim about how many institutions have chosen to fund CRITICAL PATH INSTITUTE.
Largest funder’s share by year: 2017 77% · 2018 92% · 2019 65% · 2020 22% · 2021 65% · 2022 69% · 2023 49% — diversifying over time.
“Effective funders” = inverse Herfindahl index (1 / Σ shareᵢ²) — the number of equal-sized funders that would give the same concentration. Trends are read to FY2023, the last fiscal year that has finished arriving. FY2024–FY2026 are still being filed and are shown unshaded; they do not move any figure on this page.
How long its funders stay
73% of CRITICAL PATH INSTITUTE's funders are still giving 3 years after their first grant; 52% give in more than one year at all.
Share of funders still giving k years after their first recorded grant, pooled across every acquisition cohort. A funder counts as retained in a year only if it made a grant that year. Measured to FY2023, the last fiscal year that has finished arriving — a funder cannot be counted as lapsed in a year most filers have not reached.
Where its funders are
CRITICAL PATH INSTITUTE draws 100% of its grant income from funders outside Arizona, across 9 states in all.
In-state vs out-of-state, by year
Funder states come from each funder’s own filing. $2.0M arriving through sponsors registered in 4 states is excluded from the map and the split above: a sponsor holds money on a donor’s behalf, so its registered address would place those dollars somewhere no donor need ever have been. Trends are read to FY2023, the last fiscal year that has finished arriving. FY2024–FY2026 are still being filed and are shown unshaded; they do not move any figure on this page.
Against its field
CRITICAL PATH INSTITUTE runs a healthier operating margin than three-quarters of the 2,843 health nonprofits its size.
this organization peer median middle 50% of peers· 2,843 health nonprofits $10M–$100M, FY2025
Government funding CRITICAL PATH INSTITUTE receives
Grants and contracts to this organization from federal (USASpending) and state checkbooks, reconciled to its EIN. $146.2M on record.
- Department of Health and Human Services$146.2M
Federal grants vs contracts are distinguished; state line items keep their reported category. Matched by name + geography (the BMF), so coverage is partial and precision-first.
Organizations like CRITICAL PATH INSTITUTE
Organizations whose mission and program text most resemble this one, by semantic similarity over every organization in the US filings — the closest peers, and often the clearest route to shared or prospective funders.
In Arizona
Nationally
Read directly from this organization’s own Form 990, as neutral context.
Where the money goes
78% of spending goes to programs.
Governance
Public support
89%
Share of support from the public (Schedule A) — the basis for its public-charity status.
Footprint & structure
Part of a family of 2 related entities
- Critical Path Institute Stichting · disregarded
- Critical Path Institute Ltd · corp_trust
Screen this organization
A dated, signed PDF of the compliance screen for CRITICAL PATH INSTITUTE: IRS status (Business Master File, Publication 78, auto-revocation), the OFAC sanctions lists, the Internal Revenue Bulletin, and California registration, with the Rev. Proc. 2018-32 §8.01 reliance elements stated element by element. Generated from the current files at the moment you download it.
Screens are triage, not determinations; a source that cannot be read reports not screened, never clear. Screen this nonprofit · How the screen works · on the API as GET /api/screening/{ein}?format=pdf
Questions and answers
- Who funds CRITICAL PATH INSTITUTE?
- CRITICAL PATH INSTITUTE (Arizona) receives grants from 21 organizations whose IRS filings report $19,882,166 to it, the largest being GATES FOUNDATION ($6,977,608). 11 of them have funded it in more than one year.
- How many funders does CRITICAL PATH INSTITUTE have?
- IRS filings report 21 organizations giving $19,882,166 in grants to CRITICAL PATH INSTITUTE, 11 of which have funded it in more than one year.
- Who is the largest funder of CRITICAL PATH INSTITUTE?
- GATES FOUNDATION is the largest funder on record, with $6,977,608 in grants. The full list of funders is on this page.
- How can an organization like CRITICAL PATH INSTITUTE find more funders?
- Start with the funders already giving here, then look at the foundations that back similar organizations in Arizona. The funding by cause and by state pages list the largest funders for a given area and how to approach them.
These figures are read directly from IRS Form 990 / 990-PF e-file XML: this organization’s own return for FY2025 (financials across 2017–2025), and the filings of 21 funders that report grants to it. “On record” means captured in the filings we have parsed — a funder that does not e-file, or whose grant detail is not itemized, will not appear. Filings run roughly 12–24 months behind. Trends on this page end at FY2023, the last fiscal year that has finished arriving; later years are shown and marked, and move no figure. Data on this page was exported October 14, 2026. What this page cannot tell you · view filing