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Alpha-1 Foundation Inc at a glanceMostly funded, not a grantmaker: see who funds it →

· Public charity

Alpha-1 Foundation Inc

The alpha-1 foundation is committed to finding a cure for alpha-1 antitrypsin deficiency and to improving the lives of people affected by alpha-1 worldwide.

$3.2M
Granted FY2025still arriving
19
Grants FY2025still arriving
13
States reached
$471k
Largest
01What it fundsRead
02The needRead
03Its granteesRead
04Its fieldRead
01What it funds
01100% classified

What it funded, over time

Every grant placed by its stated purpose and the recipient’s mission, by year, FY2021 to 2025.

Science & Tech$5.1MHealth$2.9MEducation$1.2MRecreation & Sports$150k
02FY2025 · 19 grants

Where the money goes

Grants by size, and the largest recipients.

How this is measured
The 19 grants below total $1,812,816, the rows itemized in this filing. The $3,199,012 headline is the total grant expense on the return; the other $1,386,196 is giving the schedule does not break out (grants under the $5,000 itemization floor, grants to individuals, grants on other schedules). Every figure below describes the itemized rows only.

By grant size · FY2025

  • Under $10k2 grants · $15k
  • $10k–50k6 grants · $216k
  • $50k–250k10 grants · $1.1M
  • $250k+1 grant · $471k
$63,368
Median grant
13
States reached
$47M
Total assets
Largest grants
RecipientAmount
UNIVERSITY OF FLORIDA$470,549
REGENTS OF THE UNIV OF CALIFORNIA$178,944
BRIGHAM & WOMEN'S HOSPITAL INC$174,125
BAYLOR COLLEGE OF MEDICINE$174,051
NATIONAL JEWISH HEALTH$99,723
UNIVERISTY OF CINCINNATI$99,500
CLEMSON UNIVERSITY$99,452
BOSTON MEDICAL CENTER$95,267
THE UNIVERSITY OF TEXAS$74,000
BOSTON UNIV OF INTERNAL MEDICINE$63,368
UNIVERSITY OF COLORADO$52,500
UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE INC$48,012
UNIVERSITY OF CHICAGO$45,894
CENTER FOR VETERANS RESEARCH AND EDUCATION$38,837
TRUSTEES OF BOSTON UNIVERSITY$37,250
02The need
03

Does the money reach high-need areas?

Each grant placed by the hardship in its grantee’s ZIP, against the area’s typical level.

show:

Dollar for dollar, its grants (FY21–25) land where the poverty rate runs at 16%, against an area that typically sits at 11%. 93% of its dollars go to grantees based in above-average-need neighborhoods. Most of its grants land in higher-need ZIPs.

area typical 11%Mass Inst of Technology: $125k → 8%Brigham & Women's Hospital: $397k → 16%Mayo Clinic: $100k → 9%Regents of the University of California Los Angeles: $234k → 14%REGENTS OF THE UNIV OF CALIFORNIA: $179k → 16%Columbia University: $300k → 17%Baylor College of Medicine: $100k → 16%Clemson University: $99k → 16%University of Florida: $524k → 19%UNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE INC: $48k → 16%Saint Louis University: $190k → 21%National Jewish Health: $140k → 12%UNIVERISTY OF CINCINNATI: $100k → 17%Northwestern University: $82k → 14%University of Kentucky: $100k → 15%Mass Inst of Technology: $74k → 8%Brigham & Women's Hospital: $199k → 16%Mayo Clinic: $99k → 9%Columbia University: $256k → 17%Baylor College of Medicine: $99k → 16%Clemson University: $74k → 16%UNIVERSITY OF FLORIDA: $471k → 19%Saint Louis University: $82k → 21%National Jewish Health: $125k → 12%Northwestern University: $68k → 14%University of Kentucky: $94k → 15%Brigham & Women's Hospital: $199k → 16%Columbia University: $234k → 17%Clemson University: $56k → 16%University of Florida: $457k → 19%NATIONAL JEWISH HEALTH: $100k → 12%University of Chicago: $62k → 14%BRIGHAM & WOMEN'S HOSPITAL INC: $174k → 16%Columbia University: $141k → 17%National Jewish Health: $40k → 12%UNIVERSITY OF CHICAGO: $46k → 14%Brigham & Women's Hospital: $100k → 16%Boston Medical Center: $100k → 16%University of Colorado: $70k → 12%Boston Medical Center: $100k → 16%UNIVERSITY OF COLORADO: $53k → 12%Boston Medical Center: $100k → 16%Univ of Colorado at Denver: $46k → 12%BOSTON MEDICAL CENTER: $95k → 16%BOSTON UNIV OF INTERNAL MEDICINE: $63k → 16%Boston University: $186k → 16%Boston University: $146k → 16%Boston University: $80k → 16%0%20%40%50%more need →
grant to an above-average-need area below average· circle size = grant amount
How this is measured
Matched: human-services grants are those whose grantee’s IRS cause code is Human Services. Placed by people below the poverty line in the grantee’s ZIP, averaged from the tracts in that ZIP.

Which US states its grants reach

MN
IL
NY
MA
OH
CT
CA
UT
CO
MO
KY
MD
KS
NC
SC
AL
TX
FL

Grants abroad, by region: $1.3M on the FY2025 return

Schedule F, as filed: 3 regions. The IRS asks for region and purpose, not the recipient, so no country or grantee can be named here.

Europe (including Iceland and Greenland)$1.0M · 79% · 11 grants

Stated purpose: RESEARCH

North America (Canada and Mexico)$200k · 15% · 1 grant

Stated purpose: RESEARCH

East Asia and the Pacific$74k · 6% · 1 grant

Stated purpose: RESEARCH

How this is measured
US grants placed by each grantee’s ZIP, which can differ from where services are delivered. Need from public data (U.S. Census/ACS, CDC PLACES, Eviction Lab, USDA), shown as context about the area, never attributed to the funder’s giving. Grants abroad on Schedule F are filed by region, purpose and amount with no recipient name, so they are shown by region and cannot be placed on the country map or matched to a grantee.
03Its grantees
repeat funding

Who it funds again

Organizations funded in more than one year, against those funded once.

88%of every dollar goes to organizations it has funded before.
$7.0M · 17 repeat orgs$949k to everyone else

17 repeat relationships: 10 still active in FY2025, 7 since wound down; 8 grantees were first funded in FY2025 (too recent to call).

How the two cohorts compare

Re-uppedFunded once

Organizations

17
4

Total granted

$7.0M
$469k

Median revenue growth · since first grant

+6%
+43%

Still filing today

59%
50%

New vs renewed · share of each year

In FY2025, 73% of grant dollars renewed an existing relationship; $480k went to new ones.

50%100%’21’22’23’24’25
RenewedFirst-time

Where new relationships form · theme of each grantee’s first grant

’21’22’23’24’25
EducationHealthScience & TechRecreation & SportsOther
How this is measured
First-time means a grantee’s first year in the filing window; renewed means funded in an earlier year too. The renewed share climbs naturally as a portfolio matures, so the signal is a year that bucks it (a wave of new grantees). The earliest year is left-censored: relationships that predate the data read as new. Theme is the grantee’s IRS cause.

Backed again, and grew

  • BC
    Baylor College of Medicine
    4× · 2021–2025 · $497k · revenue +32%
  • TRUSTEES OF BOSTON UNIVERSITY
    4× · 2021–2025 · $449k · revenue +24%
  • NATIONAL JEWISH HEALTH
    4× · 2022–2025 · $405k · revenue +5%

Funded once

  • RU
    REGENTS UNIV OF CALIFORNIA
    one grant, 2024 · $234k
  • TR
    The Research Foundation for The State University of New Yorkgraduated
    one grant, 2021 · $200k · revenue +43%
  • UO
    UNIVERSITY OF NORTH TEXAS
    one grant, 2021 · $23k
How this is measured

Repeat means funded in two or more distinct years. Growth and survival are read from each grantee’s own subsequent IRS filings.

04Its field

Closest unfunded matches

The nonprofits that most resemble its grantees but are not funded by it, scored along the direction from the rest of the field toward the portfolio. A resemblance in what they say they do, not a recommendation.

1
New York University

Nyu is a private university with approximately 60,000 matriculating students in 20 schools and institutes. nyu's primary missions are education, research and scholarship, and patient care.

Education
2
Cornell University

Education, research, medical services and other public services.

Education
3
President and Fellows of Harvard College

Undergraduate, graduate, and professional education and research across a broad array of academic domains.

Education
4
Trustees of Tufts College

Education and Research

Education
5
Case Western Reserve University

Case Western Reserve University is an independent, research-oriented university with broadly based strengths in health, including medicine, nursing and dentistry; in engineering; in the arts and sciences; and in law, management and social…

Education
6
William Marsh Rice University

As a leading research university with a distinctive commitment to undergraduate education, Rice University aspires to path breaking research, unsurpassed teaching, and contributions to the betterment of our world. It seeks to fulfill this…

Education
7
Albany College of Pharmacy and Health Sciences

We educate the next generation of leaders to improve the health of our society.

Education
8
Neurology Associates of Stony Brook University Faculty Practice Corp

Provide clinical instruction to and supervision of medical school students, interns and residents and, incident thereto, rendering professional services.

Health
9
American College of Radiology

The american college of radiology (acr) is organized to advance radiology science, practice and access, improve quality and safety, provide continuing education for radiology and allied professionals, and achieve better outcomes through…

Health
10
The George Washington University

The mission of the george washington university (gw) is to educate individuals in liberal arts, languages, sciences, learned professions, and other courses and subjects of study, and to conduct scholarly research and publish the findings…

Education
11
The Trustees of Princeton University

Research, education and general - princeton university is a private not-for-profit, non-sectarian institution of higher learning with approximately 5,700 undergraduate and 3,300 graduate students. 2,500 students graduated in the 2024-2025…

Education
12
New York Genome Center Inc

Operate a state-of-the-art, world-class genomic research center that creates and uses advanced genomics to understand the genetic basis of disease. for more information, see schedule o.

Health
How this is measured
The grantee most central to the portfolio’s shape is University of Kentucky Research Foundation; the most unlike its peers is National Jewish Health. Resemblance is measured on each organization’s own IRS 990 mission text; it reflects how work is described, not its quality or impact.
04the grantee network

19 grantees tracked through their own filings, 2017–2025.

Each grant beside the grantee’s revenue from every source, year by year.

How this is measured

Counted here: distinct organizations funded across 2017 to 2025, not grant rows in a single year, so this will not match the grant count on the cover. 19 of the 32 grantees resolved in that span have returns of their own we could reconcile.

Each grantee is resolved to its own IRS returns. Association, dated; never a causal claim.

0
Load-bearing (≥25% of a budget)
0
Early backer (in before they grew)
18/19
Grantees still filing
12/19
Grew since first funded

Where the money sits, by cause and then by grantee

UNIVERSITY OF FLORIDA: $2,388,571 · OtherUNIVERSITY OF FLORIDAMASS GENERAL BRIGHAM INCORPORATED: $1,069,500 · OtherMASS GENERAL BRIGHAM INCORPORATEDTRUSTEES OF BOSTON UNIVERSITY: $449,301 · OtherTRUSTEES OF BOSTON UNIVERSITYCLEMSON UNIVERSITY: $329,399 · OtherCLEMSON UNIVERSITYBOARD OF THE UNIVERSITY OF ALABAMA: $273,000 · OtherREGENTS UNIV OF CALIFORNIA: $233,749 · OtherREGENTS OF THE UNIVERSITY OF COLORADO: $216,034 · Other+11 more: $685,243 · Other+11 moreTHE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK: $967,720 · EducationTHE TRUSTEES OF COLUMBIA UNIV…Baylor College of Medicine: $497,401 · EducationBaylor College of MedicineST LOUIS UNIVERSITY: $277,261 · EducationST LOUIS UNIVERSITYThe Research Foundation for The State University of New York: $200,000 · EducationThe Research Foundation for T…Massachusetts Institute of Technology: $199,000 · EducationMassachusetts Institute of Te…University of Kentucky Research Foundation: $194,340 · EducationUniversity of Kentucky Resear…University of Chicago: $108,042 · EducationNATIONAL JEWISH HEALTH: $404,596 · HealthNATIONAL JEW…BOSTON MEDICAL CENTER CORPORATION: $394,267 · HealthBOSTON MEDIC…MAYO CLINIC: $199,000 · HealthMAYO CLINICCENTER FOR VETERANS RESEARCH AND EDUCATION: $38,837 · HealthNorthwestern University: $149,850 · Recreation & SportsUniversity of Kansas Center for Research Inc: $64,016 · Science & TechGORDON RESEARCH CONFERENCES INC: $7,500 · Science & Tech
Other$5,644,797Education$2,443,764Health$1,036,700Recreation & Sports$149,850Science & Tech$71,516

Each grantee by its size and the funder’s share of it; top left is load-bearing

25%50%75%100%$10M$100Mgrantee revenue →↑ funder's share of their budgetTHE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK: $967,720 over 5y, 0.0% of budgetBaylor College of Medicine: $497,401 over 4y, 0.0% of budgetTRUSTEES OF BOSTON UNIVERSITY: $449,301 over 4y, 0.0% of budgetNATIONAL JEWISH HEALTH: $404,596 over 4y, 0.0% of budgetBOSTON MEDICAL CENTER CORPORATION: $394,267 over 4y, 0.0% of budgetST LOUIS UNIVERSITY: $277,261 over 3y, 0.0% of budgetThe Research Foundation for The State University of New York: $200,000 over 1y, 0.0% of budgetMassachusetts Institute of Technology: $199,000 over 2y, 0.0% of budgetMAYO CLINIC: $199,000 over 2y, 0.0% of budgetUniversity of Kentucky Research Foundation: $194,340 over 2y, 0.0% of budgetNorthwestern University: $149,850 over 2y, 0.0% of budgetUniversity of Chicago: $108,042 over 2y, 0.0% of budgetNATIONAL ORGANIZATION FOR RARE DISORDERS INC: $105,000 over 4y, 0.1% of budgetUniversity of Kansas Center for Research Inc: $64,016 over 2y, 0.0% of budgetCENTER FOR VETERANS RESEARCH AND EDUCATION: $38,837 over 1y, 0.5% of budgetThe Chest Foundation: $12,500 over 1y, 0.3% of budgetGORDON RESEARCH CONFERENCES INC: $7,500 over 1y, 0.0% of budget
Grantee by grantee: a decade per organization, before and after funding

A decade per grantee: revenue shaded, grants as bars, all rows on one timeline.

Co-funders

Grantmakers whose grantees overlap with this funder’s far more than size alone predicts. Closer means stronger alignment; arcs show where they also fund each other. Here they form a tightly interlocked group: most of these funders back each other's grantees too.

National Philanthropi…Donor Advised Charita…Fidelity Investments …Amazonsmile Foundation
National Philanthropic TrustPA8.3× affinity4 shared granteesties to 3 of 3Hover any node to trace its alignments.Compare side by side →

Open a dossier: National Philanthropic Trust · Donor Advised Charitable Giving Inc · Fidelity Investments Charitable Gift Fund · Amazonsmile Foundation

How this is measured
Affinity is a Gamma-Poisson posterior co-funding rate, re-centered on the typical rate, so thin evidence shrinks toward no signal. Overlap is association, not proof of shared intent.

How much its grantees rely on government

Each dot is one organization Alpha-1 Foundation Inc funds: left to right is the share of its income from government, bottom to top the share from Alpha-1 Foundation Inc. Bigger dots raise more.

2024
’20’21’22’23’24’25
no gov · 00%0%1%3%5%funder's share of their income ↑0%23%45%68%90%share of the org’s income from government →median 23%
  • Massachusetts Institute of Technology: 35% of income from government
  • Boston Medical Center Corporation: 23% of income from government
  • Federation of American Societies for Experimental Biology: 14% of income from government
  • Trustees of Boston University: 12% of income from government
no gov moneyreceives it· size = income
0get no government money at all
2report government grants on their 990 we could not trace to a source (not plotted)
0rely on government for over half their income
⤢ axis zoomed · 0–90%
typical government reliance, FY20–25
How this is measured
Government income is each org’s traced federal awards (USASpending grants and contracts) plus state payments (open checkbooks) as a share of its total revenue (IRS Form 990); the self-reported government-grant line (990 line 1e) is carried for cross-check: a grantee that reports government grants we could not trace to a source is left off the chart rather than shown as receiving none. An association, not a claim that a grant caused the public funding. Coverage is precision-first, a floor rather than a census; state records exist for 9 states, so a grantee outside them shows no state figure (dimmed) rather than a false zero. Federal award amounts are obligations, which can span years, so a single-year share is indicative. 990 filings lag 12 to 24 months.

On method. Every financial figure here is read from IRS e-file XML, the funder’s own 990/990-PF, and from the multi-year returns of the 32 grantees we resolved, each linked to its source. Grantee outcomes are each organization’s own program-service reporting (Form 990, Part III), read as association with funding, never as caused by it. Low-confidence name matches are suppressed rather than guessed. How we build these →

How this is measured
Each figure carries one of six labels. Filed is what the funder reported on its return. Official is another government record about an organization, such as a federal award or a charity register, joined by name where no shared identifier exists. Resolved is an identity we worked out where the filing named a recipient without an EIN, kept only above a measured confidence threshold. Computed is arithmetic over those, like themes, portfolio clusters and co-funder strength. Context is a statistic about a place rather than about an organization, which is what the need overlay is: it describes the area a grantee’s address sits in, not where its work lands. Inferred is drawn by a model from text, like the partnerships read out of public news and organization websites. Each is labeled where it appears.

Generated from the IRS Form 990 e-file return for fiscal year 2025, released 2025. Filings run roughly 12 to 24 months behind; figures are dated accordingly.

Source object · view filing

Play a game based on Alpha-1’s filings →

More from the funding graph

The unnamed billions
grants reported with no recipient in the public record
The regranting layer
51% of grant dollars land in the regranting layer
The DAF merry-go-round
$9.7B circulates between donor-advised funds
The endowment market
who holds foundation money, and what just moved
The camps
funders cluster by geography, not ideology
By state
where grant money is based, and what stays home