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Florida · Public charity

Alpha-1 Foundation Inc

The alpha-1 foundation is committed to finding a cure for alpha-1 antitrypsin deficiency and to improving the lives of people affected by alpha-1 worldwide.

$3.2M
Granted FY2025(still arriving)
19
Itemized grants FY2025
13
Organizations funded FY2024
23%
First-time grantees FY2024
Read the full brief
Itemized, FY2025
$1.8M
The rest is grants the schedule does not break out
Median grant, FY2025
$63,368
Largest grant, FY2025
$470,549
Organizations funded a year
12 to 14
FY2021 to FY2024
States reached, FY2025
13
Total assets, FY2025
$47M

How open it is to new grantees

In FY2024, 23% of the organizations Alpha-1 Foundation Inc funded were first-time grantees, receiving 16% of its grant dollars.

New vs renewed · share of each year

In FY2024, 84% of grant dollars renewed an existing relationship; $312k went to new ones.

50%100%’22’23’24
RenewedFirst-time

Where new relationships form · theme of each grantee’s first grant

’22’23’24
EducationHealthRecreation & SportsScience & TechOther
How this is measured
First-time means a grantee’s first year in the filing window; renewed means funded in an earlier year too. The renewed share climbs naturally as a portfolio matures, so the signal is a year that bucks it (a wave of new grantees). The earliest year is left-censored: relationships that predate the data read as new. Theme is the grantee’s IRS cause.
The numbers by year
Fiscal yearOrganizations fundedTo those organizationsFirst-time grantees
FY2025still arriving18$1.8M44%
FY202413$2.0M23%
FY202312$1.4M0%
FY202213$1.2M31%
FY202114$1.6Mn/a
100% classified

What it funded, over time

Every grant placed by its stated purpose and the recipient’s mission, by year, FY2021 to 2025.

Science & Tech$5.1MHealth$2.9MEducation$1.2MRecreation & Sports$150k

Where its grants go

Grant dollars by states, across the years we hold.

Which US states its grants reach

MN
IL
NY
MA
OH
CT
CA
UT
CO
MO
KY
MD
KS
NC
SC
AL
TX
FL

Top grantees

Largest recipients by total granted, FY2021 to FY2025, and the share of each one’s budget the grants supplied at peak.

GranteeTotal grantedYearsShare of their budget
University of Florida$2,388,5715n/a
Mass General Brigham Incorporated$1,069,5005n/a
Baylor College of Medicine$497,40140%
Trustees of Boston University$449,30140%
National Jewish Health$404,59640%
Boston Medical Center Corporation$394,26740%
Clemson University$329,3994n/a
St Louis University$277,26130%
Board of the University of Alabama$273,0003n/a
Regents Univ of California$233,7491n/a
Show all 29 grantees
All grantees of Alpha-1 Foundation Inc by total granted
GranteeTotal grantedYearsShare of their budget
University of Florida$2,388,5715n/a
Mass General Brigham Incorporated$1,069,5005n/a
Baylor College of Medicine$497,40140%
Trustees of Boston University$449,30140%
National Jewish Health$404,59640%
Boston Medical Center Corporation$394,26740%
Clemson University$329,3994n/a
St Louis University$277,26130%
Board of the University of Alabama$273,0003n/a
Regents Univ of California$233,7491n/a
Regents of the University of Colorado$216,0345n/a
The Research Foundation for The State University of New York$200,00010%
University of Kentucky Research Foundation$194,34020%
University of California Davis$178,9441n/a
Northwestern University$149,85020%
University of Chicago$108,04220%
National Organization for Rare Disorders Inc$105,00040%
University of Cincinnati$99,5001n/a
University of Texas$74,0001n/a
University of Kansas Center for Research Inc$64,01620%
Evans Medical Foundation Inc$63,3681n/a
Ats Foundation Inc$60,0002n/a
University of North Carolina at Chapel Hill$50,8973n/a
Center for Veterans Research and Education$38,83711%
University of North Texas$23,0351n/a
The Chest Foundation$12,50010%
University of Utah$10,4991n/a
Gordon Research Conferences Inc$7,50010%
Federation of American Societies for Experimental Biology$7,5001n/a

Where it is load-bearing

Each grantee by its size and the share of its budget Alpha-1 Foundation Inc supplied at peak.

25%50%75%100%$10M$100Mgrantee revenue →↑ funder's share of their budgetBaylor College of Medicine: $497,401 over 4y, 0.0% of budgetTrustees of Boston University: $449,301 over 4y, 0.0% of budgetNational Jewish Health: $404,596 over 4y, 0.0% of budgetBoston Medical Center Corporation: $394,267 over 4y, 0.0% of budgetSt Louis University: $277,261 over 3y, 0.0% of budgetThe Research Foundation for The State University of New York: $200,000 over 1y, 0.0% of budgetUniversity of Kentucky Research Foundation: $194,340 over 2y, 0.0% of budgetNorthwestern University: $149,850 over 2y, 0.0% of budgetUniversity of Chicago: $108,042 over 2y, 0.0% of budgetNational Organization for Rare Disorders Inc: $105,000 over 4y, 0.1% of budgetUniversity of Kansas Center for Research Inc: $64,016 over 2y, 0.0% of budgetCenter for Veterans Research and Education: $38,837 over 1y, 0.5% of budgetThe Chest Foundation: $12,500 over 1y, 0.3% of budgetGordon Research Conferences Inc: $7,500 over 1y, 0.0% of budget

Tap a dot to name the grantee.

How this is measured
Share of budget is the funder’s grant in a year over the grantee’s total revenue that year, at its highest across the years we hold; revenue is from all sources. Only grantees confirmed against their own filings, whose grants do not exceed their revenue, are plotted: the largest 14.

Nonprofits that may fit its grantmaking

Co-funders

Grantmakers whose grantees overlap with this funder’s far more than size alone predicts. Closer means stronger alignment; arcs show where they also fund each other. Here they form a tightly interlocked group: most of these funders back each other's grantees too.

National Philanthropic TrustPA8.3× affinity4 shared granteesties to 3 of 3Hover any node to trace its alignments.Compare side by side →

Open a dossier: National Philanthropic Trust · Donor Advised Charitable Giving Inc · Fidelity Investments Charitable Gift Fund · Amazonsmile Foundation

How this is measured
Affinity is a Gamma-Poisson posterior co-funding rate, re-centered on the typical rate, so thin evidence shrinks toward no signal. Overlap is association, not proof of shared intent.

Compare Alpha-1 Foundation Inc with peer funders

About Alpha-1 Foundation Inc

How much does Alpha-1 Foundation Inc give?
Alpha-1 Foundation Inc reported 19 itemized grants totaling $1,812,816, out of $3,199,012 in total grant expense reported on the return in its FY2025 IRS filing. It funded between 12 and 14 organizations a year over FY2021 to FY2024.
What does Alpha-1 Foundation Inc fund?
By grant dollars over FY2021 to FY2025, its largest causes are Science & Tech (55%), Health (31%), Education (12%).
Who are Alpha-1 Foundation Inc's largest grantees?
By total granted over FY2021 to FY2025: University of Florida ($2.4M), Mass General Brigham Incorporated ($1.1M), Baylor College of Medicine ($497k).
Does Alpha-1 Foundation Inc fund new organizations?
In FY2024, 23% of the organizations it funded were first-time grantees.
Which funders back the same organizations as Alpha-1 Foundation Inc?
Its strongest co-funders, measured against what their size predicts, include National Philanthropic Trust, Donor Advised Charitable Giving Inc, Fidelity Investments Charitable Gift Fund.
Where is Alpha-1 Foundation Inc based?
Alpha-1 Foundation Inc is based in FL.

On method. Every financial figure here is read from IRS e-file XML, the funder’s own 990/990-PF, and from the multi-year returns of the 32 grantees we resolved, each linked to its source. Grantee outcomes are each organization’s own program-service reporting (Form 990, Part III), read as association with funding, never as caused by it. Low-confidence name matches are suppressed rather than guessed. How we build these →

How this is measured
Each figure carries one of six labels. Filed is what the funder reported on its return. Official is another government record about an organization, such as a federal award or a charity register, joined by name where no shared identifier exists. Resolved is an identity we worked out where the filing named a recipient without an EIN, kept only above a measured confidence threshold. Computed is arithmetic over those, like themes, portfolio clusters and co-funder strength. Context is a statistic about a place rather than about an organization, which is what the need overlay is: it describes the area a grantee’s address sits in, not where its work lands. Inferred is drawn by a model from text, like the partnerships read out of public news and organization websites. Each is labeled where it appears.

Generated from the IRS Form 990 e-file return for fiscal year 2025, released 2025. Filings run roughly 12 to 24 months behind; figures are dated accordingly.

Source object · view filing

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