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· Public charity

Breakthrough T1d

BREAKTHROUGH T1D is the leading global t1d organization working to accelerate life-changing breakthroughs to cure, prevent, and treat t1d and its complications.

$122M
Granted FY2025still arriving
100
Grants FY2025still arriving
30
States reached
$7.3M
Largest
01What it funds
0199% classified

What it funded, over time

Every grant placed by its stated purpose and the recipient’s mission, by year, FY2017 to 2025.

Health$453MEducation$68MScience & Tech$7.8MCommunity Improvement$1.8MEmployment$1.6MInternational$493kRecreation & Sports$310kOther$0
02FY2025 · 100 grants

Where the money goes

Grants by size, and the largest recipients.

How this is measured
The 100 grants below total $79,319,658, the rows itemized in this filing. The $121,747,047 headline is the total grant expense on the return; the other $42,427,389 is giving the schedule does not break out (grants under the $5,000 itemization floor, grants to individuals, grants on other schedules). Every figure below describes the itemized rows only.

By grant size · FY2025

  • $10k–50k2 grants · $60k
  • $50k–250k29 grants · $4.4M
  • $250k+69 grants · $75M
$382,730
Median grant
30
States reached
$535M
Total assets
Largest grants
RecipientAmount
UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL$7,275,001
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA SAN FRANCISCO$5,397,345
THE UNIVERSITY OF CHICAGO$4,120,701
REGENTS OF THE UNIVERSITY OF COLORADO$3,578,005
UNIVERSITY OF FLORIDA$3,130,295
THE BRIGHAM AND WOMENS HOSPITAL INC$2,749,635
JOSLIN DIABETES CENTER INC$2,565,662
TRUSTEES OF INDIANA UNIVERSITY$2,492,689
UNIVERSITY OF WASHINGTON$2,386,866
REGENTS OF THE UNIVERSITY OF MICHIGAN$2,251,674
UNIVERSITY OF MIAMI$2,173,204
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI$1,868,623
CLINTON HEALTH ACCESS INITIATIVE (CHAI)$1,734,554
REGENTS OF THE UNIVERSITY OF MINNESOTA$1,594,731
RECTOR & VISITORS OF THE UNIVERSITY OF VIRGINIA$1,549,988
02The need
03

Does the money reach high-need areas?

Each grant placed by the hardship in its grantee’s ZIP, against the area’s typical level.

show:

Its human-services grants (FY22–23, $6.0M) land where the poverty rate runs at 8%, against an area that typically sits at 10%. 0% of those dollars go to grantees based in above-average-need neighborhoods. Its grants skew toward lower-need ZIPs.

area typical 10%CIVICA RX: $3.0M → 8%CIVICA RX: $3.0M → 8%0%20%40%50%more need →
grant to an above-average-need area below average· circle size = grant amount
How this is measured
Matched: human-services grants are those whose grantee’s IRS cause code is Human Services. Placed by people below the poverty line in the grantee’s ZIP, averaged from the tracts in that ZIP.

Which US states its grants reach

ME
NH
WA
MN
IL
WI
MI
NY
MA
OR
SD
IA
IN
OH
PA
NJ
CT
RI
CA
UT
CO
NE
MO
WV
VA
MD
AZ
KS
AR
TN
NC
SC
DC
OK
LA
AL
GA
TX
FL

Grants abroad, by region: $43M on the FY2025 return

Schedule F, as filed: 5 regions. The IRS asks for region and purpose, not the recipient, so no country or grantee can be named here.

Europe (including Iceland and Greenland)$24M · 57% · 54 grants

Stated purpose: T1D RESEARCH

North America (Canada and Mexico)$8.9M · 21% · 12 grants

Stated purpose: T1D RESEARCH

East Asia and the Pacific$5.8M · 13% · 14 grants

Stated purpose: T1D RESEARCH

Middle East and North Africa$2.1M · 5% · 5 grants

Stated purpose: T1D RESEARCH

South Asia$1.6M · 4% · 3 grants

Stated purpose: T1D RESEARCH

How this is measured
US grants placed by each grantee’s ZIP, which can differ from where services are delivered. Need from public data (U.S. Census/ACS, CDC PLACES, Eviction Lab, USDA), shown as context about the area, never attributed to the funder’s giving. Grants abroad on Schedule F are filed by region, purpose and amount with no recipient name, so they are shown by region and cannot be placed on the country map or matched to a grantee.
03Its grantees
repeat funding

Who it funds again

Organizations funded in more than one year, against those funded once.

96%of every dollar goes to organizations it has funded before.
$462M · 154 repeat orgs$21M to everyone else

Grantees it renews have grown median revenue +49% since the first grant, against +43% for those funded once.

154 repeat relationships: 82 still active in FY2025, 72 since wound down; 12 grantees were first funded in FY2025 (too recent to call).

How the two cohorts compare

Re-uppedFunded once

Organizations

154
59

Total granted

$462M
$17M

Median revenue growth · since first grant

+49%
+43%

Still filing today

47%
32%

New vs renewed · share of each year

In FY2025, 94% of grant dollars renewed an existing relationship; $4.2M went to new ones.

50%100%’17’18’19’20’21’22’23’24’25
RenewedFirst-time

Where new relationships form · theme of each grantee’s first grant

’17’18’19’20’21’22’23’24’25
EducationHealthScience & TechInternationalHuman ServicesRecreation & SportsOther
How this is measured
First-time means a grantee’s first year in the filing window; renewed means funded in an earlier year too. The renewed share climbs naturally as a portfolio matures, so the signal is a year that bucks it (a wave of new grantees). The earliest year is left-censored: relationships that predate the data read as new. Theme is the grantee’s IRS cause.

Backed again, and grew

  • THE UNIVERSITY OF FLORIDA FOUNDATION INC
    5× · 2017–2021 · $19M · revenue +56%
  • UO
    UNIVERSITY OF COLORADO FOUNDATION
    5× · 2017–2021 · $16M · revenue +79%
  • JC
    JAEB CENTER FOR HEALTH RESEARCH FOUNDATION INC
    9× · 2017–2025 · $14M · revenue +81%

Funded once

  • RO
    REGENTS OF THE UNIVERSITY OF CALIFORNIA
    one grant, 2021 · $2.7M
  • SF
    SFC FLUIDICS INC
    one grant, 2020 · $1.5M
  • AE
    AVEL ECARE
    one grant, 2021 · $1.3M
How this is measured

Repeat means funded in two or more distinct years. Growth and survival are read from each grantee’s own subsequent IRS filings.

04Its field

Closest unfunded matches

The nonprofits that most resemble its grantees but are not funded by it, scored along the direction from the rest of the field toward the portfolio. A resemblance in what they say they do, not a recommendation.

1
New York University

Nyu is a private university with approximately 60,000 matriculating students in 20 schools and institutes. nyu's primary missions are education, research and scholarship, and patient care.

Education
2
Albany College of Pharmacy and Health Sciences

We educate the next generation of leaders to improve the health of our society.

Education
3
Rush University Medical Center

The mission of Rush is to improve the health of the individuals and diverse communities we serve through the integration of outstanding patient care, education, research and community partnerships.

Health
4
Fred Hutchinson Cancer Center

Fred hutch cancer center ("fred hutch") unites innovative research and compassionate care to prevent and eliminate cancer and infectious disease. continued on schedule o

Health
5
University of Minnesota Physicians

University of minnesota physicians serves as the integrated group practice for the university of minnesota medical school full-time faculty to provide the highest quality healthcare to patients and their families.university of minnesota…

Health
6
Thomas Jefferson University

Thomas jefferson university ("tju") is a comprehensive university with preeminence in transdisciplinary, experiential professional education, research and discovery, delivering exceptional value for the 21st century students with…

Education
7
The Johns Hopkins Hospital

For more than 125 years, the mission of the johns hopkins hospital has been to lead the world in the diagnosis and treatment of disease and to train tomorrow's great physicians, nurses and scientists. above all, we aim to provide the…

Health
8
New York Genome Center Inc

Operate a state-of-the-art, world-class genomic research center that creates and uses advanced genomics to understand the genetic basis of disease. for more information, see schedule o.

Health
9
Massachusetts Eye & Ear Infirmary

THE MASSACHUSETTS EYE AND EAR INFIRMARY ("THE INFIRMARY") IS A NOT-FOR-PROFIT TEACHING HOSPITAL CONDUCTING PATIENT CARE AND RESEARCH. THE INFIRMARY IS A TEACHING HOSPITAL OF HARVARD MEDICAL SCHOOL AND AN INTERNATIONAL CENTER FOR RESEARCH.…

Health
10
Trustees of Boston University

Organization's mission: boston university is an international, comprehensive, private research university, committed to educating students to be reflective, resourceful individuals ready to live, adapt, and lead in an interconnected world.…

—
11
Rhode Island Hospital

As a founding hospital in the brown university health system, rih is committed to its mission: delivering health with care.

Health
12
Institute for Advanced Study - Louis Bamberger & Mrs Felix Fuld Foundation

The institute for advanced study (the institute) is one of the world's leading centers for theoretical research and intellectual inquiry. see schedule o.

Science & Tech
How this is measured
The grantee most central to the portfolio’s shape is University of Chicago; the most unlike its peers is The University of the Seven Rays. Resemblance is measured on each organization’s own IRS 990 mission text; it reflects how work is described, not its quality or impact.
04the grantee network

108 grantees tracked through their own filings, 2017–2025.

Each grant beside the grantee’s revenue from every source, year by year.

How this is measured

Counted here: distinct organizations funded across 2017 to 2025, not grant rows in a single year, so this will not match the grant count on the cover. 108 of the 235 grantees resolved in that span have returns of their own we could reconcile.

Each grantee is resolved to its own IRS returns. Association, dated; never a causal claim.

5
Load-bearing (≥25% of a budget)
6
Early backer (in before they grew)
106/108
Grantees still filing
95/108
Grew since first funded

Where the money sits, by cause and then by grantee

REGENTS UNIV OF CALIFORNIA: $19,379,216 · OtherREGENTS UNIV OF CALIFORNIAREGENTS OF THE UNIVERSITY OF COLORADO: $18,086,834 · OtherREGENTS OF THE UNIVERSITY OF COLORADOUNIVERSITY OF CALIFORNIA SAN FRANCISCO: $15,900,429 · OtherUNIVERSITY OF CALIFORNIA SAN FRANCISCOUNIVERSITY OF MASSACHUSETTS: $14,907,100 · OtherUNIVERSITY OF MASSACHUSETTSREGENTS OF THE UNIVERSITY OF MICHIGAN: $14,601,118 · OtherREGENTS OF THE UNIVERSITY OF MICHIGANJAEB CENTER FOR HEALTH RESEARCH FOUNDATION INC: $13,713,033 · OtherUNIVERSITY OF MINNESOTA: $13,633,044 · OtherUNIVERSITY OF FLORIDA: $11,240,484 · Other+102 more: $137,791,666 · Other+102 morePresident and Fellows of Harvard College: $21,195,351 · EducationPresident and Fellows of Harvard …THE UNIVERSITY OF FLORIDA FOUNDATION INC: $18,590,888 · EducationTHE UNIVERSITY OF FLORIDA FOUNDAT…UNIVERSITY OF COLORADO FOUNDATION: $15,919,261 · EducationUNIVERSITY OF COLORADO FOUNDATIONUniversity of Miami: $12,790,378 · EducationUniversity of MiamiTHE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY: $9,324,119 · EducationTHE BOARD OF TRUSTEES OF THE LELA…Yale University: $7,260,423 · EducationICAHN SCHOOL OF MEDICINE AT MOUNT SINAI: $5,595,493 · EducationUniversity of Chicago: $5,220,583 · Education+35 more: $59,922,309 · Education+35 moreJOSLIN DIABETES CENTER INC: $15,181,341 · HealthJOSLIN DIABETES CENT…Tidepool Project: $10,989,664 · HealthTidepool ProjectBENAROYA RESEARCH INSTITUTE AT VIRGINIA: $10,310,420 · HealthBENAROYA RESEARCH IN…BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE: $10,278,499 · HealthBECKMAN RESEARCH INS…T1D EXCHANGE INC: $5,944,696 · HealthT1D EXCHANGE INCPhysicians Organization at Children's Hospital Inc: $4,231,441 · Health+31 more: $37,588,496 · Health+31 moreResearch Triangle Institute: $4,112,351 · Science & TechIndiana Biosciences Research Institute Inc: $2,465,017 · Science & TechUniversity of Kansas Center for Research Inc: $499,994 · Science & Tech+2 more: $399,517 · Science & TechCIVICA FOUNDATION: $6,000,000 · Human ServicesAdvanced Regenerative Manufacturing Institute Inc: $3,240,118 · Community ImprovementBROWN UNIVERSITY: $1,189,619 · Community ImprovementNorthwestern University: $2,444,924 · Recreation & SportsCLINTON HEALTH ACCESS INITIATIVE INC: $1,734,554 · International
Other$259,252,924Education$155,818,805Health$94,524,557Science & Tech$7,476,879Human Services$6,000,000Community Improvement$4,429,737Recreation & Sports$2,444,924International$1,734,554

Showing the 200 largest grantees by grant value.

Each grantee by its size and the funder’s share of it; top left is load-bearing

25%50%75%100%$1.0M$10M$100Mgrantee revenue →↑ funder's share of their budgetPresident and Fellows of Harvard College: $21,195,351 over 8y, 0.1% of budgetTHE UNIVERSITY OF FLORIDA FOUNDATION INC: $18,590,888 over 5y, 7.6% of budgetUNIVERSITY OF COLORADO FOUNDATION: $15,919,261 over 5y, 1.7% of budgetJOSLIN DIABETES CENTER INC: $15,181,341 over 9y, 4.0% of budgetJAEB CENTER FOR HEALTH RESEARCH FOUNDATION INC: $13,713,033 over 9y, 12% of budgetUniversity of Miami: $12,790,378 over 9y, 0.1% of budgetTidepool Project: $10,989,664 over 8y, 88% of budgetBENAROYA RESEARCH INSTITUTE AT VIRGINIA: $10,310,420 over 8y, 4.0% of budgetBECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE: $10,278,499 over 8y, 1.1% of budgetTHE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY: $9,324,119 over 9y, 0.0% of budgetYale University: $7,260,423 over 9y, 0.0% of budgetCIVICA FOUNDATION: $6,000,000 over 2y, 17% of budgetT1D EXCHANGE INC: $5,944,696 over 7y, 25% of budgetICAHN SCHOOL OF MEDICINE AT MOUNT SINAI: $5,595,493 over 6y, 0.0% of budgetUniversity of Chicago: $5,220,583 over 4y, 0.1% of budgetTRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA: $5,179,821 over 9y, 0.0% of budgetWASHINGTON UNIVERSITY: $4,743,615 over 9y, 0.0% of budgetPhysicians Organization at Children's Hospital Inc: $4,231,441 over 4y, 2.6% of budgetIndiana University Foundation: $4,165,476 over 4y, 0.4% of budgetResearch Triangle Institute: $4,112,351 over 3y, 0.1% of budgetVanderbilt University: $3,823,942 over 8y, 0.1% of budgetJOHNS HOPKINS UNIVERSITY: $3,724,288 over 7y, 0.0% of budgetAlbert Einstein College of Medicine: $3,287,004 over 5y, 0.3% of budgetMassachusetts Institute of Technology: $3,262,684 over 7y, 0.0% of budgetAdvanced Regenerative Manufacturing Institute Inc: $3,240,118 over 4y, 5.3% of budgetChildren's Hospital Corporation: $3,128,731 over 4y, 0.0% of budgetUT SOUTHWESTERN HEALTH SYSTEMS: $2,856,174 over 4y, 41% of budgetDUKE UNIVERSITY: $2,843,055 over 6y, 0.0% of budgetThe University of The Seven Rays: $2,645,009 over 5y, 42% of budgetPARKER INSTITUTE FOR CANCER IMMUNOTHERAPY: $2,609,232 over 3y, 1.7% of budgetIndiana Biosciences Research Institute Inc: $2,465,017 over 8y, 12% of budgetNorthwestern University: $2,444,924 over 4y, 0.0% of budgetVanderbilt University Medical Center: $2,380,082 over 4y, 0.0% of budgetCarnegie Mellon University: $2,350,534 over 5y, 0.1% of budgetNEW YORK STEM CELL FOUNDATION INC: $2,328,508 over 7y, 2.1% of budgetTHE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK: $2,291,443 over 8y, 0.0% of budgetUNIVERSITY OF PITTSBURGH: $2,147,295 over 5y, 0.0% of budgetThe Research Foundation for The State University of New York: $2,006,247 over 4y, 0.1% of budgetGEORGIA TECH RESEARCH CORPORATION: $1,987,570 over 9y, 0.1% of budgetAnn & Robert H Lurie Children's Hospital of Chicago: $1,938,552 over 8y, 0.0% of budgetLUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER: $1,808,960 over 4y, 1.6% of budgetWilliam Marsh Rice University: $1,800,000 over 6y, 0.0% of budgetOREGON HEALTH & SCIENCE UNIVERSITY FOUNDATION: $1,791,534 over 5y, 0.6% of budgetUNIVERSITY OF KANSAS MEDICAL CENTER RESEARCH INSTITUTE: $1,659,998 over 4y, 0.3% of budgetBETH ISRAEL MEDICAL CENTER: $1,646,572 over 3y, 0.1% of budgetUNIVERSITY OF MINNESOTA FOUNDATION: $1,582,238 over 5y, 0.2% of budgetGEISINGER CLINIC: $1,469,640 over 3y, 0.0% of budgetTHE SCRIPPS RESEARCH INSTITUTE: $1,414,624 over 3y, 0.2% of budget
Grantee by grantee: a decade per organization, before and after funding

A decade per grantee: revenue shaded, grants as bars, all rows on one timeline.

  • Who funds President and Fellows of Harvard College ↗
  • Who funds THE UNIVERSITY OF FLORIDA FOUNDATION INC ↗
  • Who funds UNIVERSITY OF COLORADO FOUNDATION ↗
  • Who funds JOSLIN DIABETES CENTER INC ↗
  • Who funds JAEB CENTER FOR HEALTH RESEARCH FOUNDATION INC ↗
  • Who funds University of Miami ↗
  • Who funds Tidepool Project ↗
  • Who funds BENAROYA RESEARCH INSTITUTE AT VIRGINIA ↗
  • Who funds BECKMAN RESEARCH INSTITUTE OF THE CITY OF HOPE ↗
  • Who funds THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY ↗
  • Who funds Yale University ↗
  • Who funds CIVICA FOUNDATION ↗
  • Who funds T1D EXCHANGE INC ↗
  • Who funds ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ↗
  • Who funds University of Chicago ↗
  • Who funds TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ↗
  • Who funds Biomedical Research Institute of America ↗
  • Who funds WASHINGTON UNIVERSITY ↗
  • Who funds Physicians Organization at Children's Hospital Inc ↗
  • Who funds Indiana University Foundation ↗
  • Who funds Research Triangle Institute ↗
  • Who funds Vanderbilt University ↗
  • Who funds JOHNS HOPKINS UNIVERSITY ↗

Co-funders

Grantmakers whose grantees overlap with this funder’s far more than size alone predicts. Closer means stronger alignment; arcs show where they also fund each other. Here they form a tightly interlocked group: most of these funders back each other's grantees too.

The Trustees of Columbia University in the City of New YorkNY36.7× affinity17 shared granteesties to 11 of 11Hover any node to trace its alignments.Compare side by side →

Open a dossier: The Trustees of Columbia University in the City of New York · Yale University · Johns Hopkins University · Mayo Clinic · American Cancer Society Inc · Vanderbilt University Medical Center · The Leona M and Harry B Helmsley Charitable Trust · American Heart Association Inc · University of Southern California · University of Pittsburgh · American Diabetes Association · Cystic Fibrosis Foundation

How this is measured
Affinity is a Gamma-Poisson posterior co-funding rate, re-centered on the typical rate, so thin evidence shrinks toward no signal. Overlap is association, not proof of shared intent.

How much its grantees rely on government

Each dot is one organization Breakthrough T1d funds: left to right is the share of its income from government, bottom to top the share from Breakthrough T1d. Bigger dots raise more.

2024
’20’21’22’23’24’25
no gov · 60%6%25%56%100%funder's share of their income ↑0%25%50%75%100%share of the org’s income from government →median 11%
  • Jaeb Center for Health Research Foundation Inc: 60% of income from government
  • Hugo W Moser Research Institute at Kennedy Krieger Inc: 39% of income from government
  • Joslin Diabetes Center Inc: 35% of income from government
  • Massachusetts Institute of Technology: 35% of income from government
  • The Broad Institute Inc: 19% of income from government
  • Trustees of Tufts College: 13% of income from government
  • Johns Hopkins University: 12% of income from government
  • Yale University: 12% of income from government
  • University of Maryland Neurosurgeryassociates Pa: 11% of income from government
  • Children's Hospital Corporation: 10% of income from government
  • President and Fellows of Harvard College: 7% of income from government
  • Dana-Farber Cancer Institute Inc: 7% of income from government
  • Beth Israel Deaconess Medical Center Inc: 6% of income from government
  • University of Miami: 5% of income from government
  • Trustees of Boston College: 3% of income from government
  • Oregon Health & Science University Foundation: 1% of income from government
  • The Nemours Foundation: 0% of income from government
no gov moneyreceives it· size = income
6get no government money at all
10report government grants on their 990 we could not trace to a source (not plotted)
1rely on government for over half their income
typical government reliance, FY20–25
How this is measured
Government income is each org’s traced federal awards (USASpending grants and contracts) plus state payments (open checkbooks) as a share of its total revenue (IRS Form 990); the self-reported government-grant line (990 line 1e) is carried for cross-check: a grantee that reports government grants we could not trace to a source is left off the chart rather than shown as receiving none. An association, not a claim that a grant caused the public funding. Coverage is precision-first, a floor rather than a census; state records exist for 9 states, so a grantee outside them shows no state figure (dimmed) rather than a false zero. Federal award amounts are obligations, which can span years, so a single-year share is indicative. 990 filings lag 12 to 24 months.

On method. Every financial figure here is read from IRS e-file XML, the funder’s own 990/990-PF, and from the multi-year returns of the 235 grantees we resolved, each linked to its source. Grantee outcomes are each organization’s own program-service reporting (Form 990, Part III), read as association with funding, never as caused by it. Low-confidence name matches are suppressed rather than guessed. How we build these →

How this is measured
Each figure carries one of six labels. Filed is what the funder reported on its return. Official is another government record about an organization, such as a federal award or a charity register, joined by name where no shared identifier exists. Resolved is an identity we worked out where the filing named a recipient without an EIN, kept only above a measured confidence threshold. Computed is arithmetic over those, like themes, portfolio clusters and co-funder strength. Context is a statistic about a place rather than about an organization, which is what the need overlay is: it describes the area a grantee’s address sits in, not where its work lands. Inferred is drawn by a model from text, like the partnerships read out of public news and organization websites. Each is labeled where it appears.

Generated from the IRS Form 990 e-file return for fiscal year 2025, released 2025. Filings run roughly 12 to 24 months behind; figures are dated accordingly.

Source object · view filing

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