Massachusetts · Nonprofit
Active Site Research Inc
Active Site Research Inc (Massachusetts) receives grants from 4 organizations whose IRS filings report $337,000 to it, the largest being Silicon Valley Community Foundation ($120,000). 0 of them have funded it in more than one year, and 71% of the money arrives through donor-advised or pass-through sponsors rather than from an institution directly.
- Revenue FY2025
- $2.3M
- Funders on record
- 4
- Grants received
- $337k
- Net assets
- $1.3M
What Active Site Research Inc does
Mission
To eliminate the risks posed by pandemic threats through the advancement of science and innovation in medical countermeasure development, ensuring the health and well-being of individuals and communities worldwide.
As stated on its FY2025 Form 990.
Programs
On its FY2024 return the organization reported starting a significant new program and a significant change in how it conducts a program.
began the PAN-2025-001 and AI/biosecurity programs (see Form 990, Part III, Lines 4b and 4c for program description)
Its own explanation, from Schedule O of that return (Part III, line 2).
Discontinued synthetic innate immunity program (see form 990, Part III, Line 4a for program description)
Its own explanation, from Schedule O of that return (Part III, line 3).
The Synthetic Innate Immunity program aims to develop medicines that serve as society's first line of defense against emerging viral outbreaks by taking inspiration from natural mechanisms of innate immunity. By encoding natural or engineered pattern recognition receptors PRRs and interferon-stimulated genes ISGs in DNA delivered to the respiratory tract, the program works to persistently enhance a patient's natural sense-and-respond capacity, potentially providing prophylactic protection against a broad range of respiratory viruses for months.
$330,152 spent41% of program spendingPAN-2025-001 is a single-site, two-arm, parallel-group superiority randomized controlled trial (RCT) with 1:1 allocation, designed to evaluate whether large language model (LLM) use improves the ability of novice lab participants to independently perform complex biological tasks. Participants attempt a fixed sequence of five laboratory obstacles that represent the core skills required to create a virus via reverse genetics with or without LLM assistance.
$235,675 spent29% of program spendingThe organization periodically provides subject-matter expertise in molecular biology and related life sciences disciplines to AI companies. Such services include responding to technical inquiries and developing advanced scientific problem sets designed to evaluate complex biological reasoning and analytical capabilities in emerging AI technologies. These activities further the organizations scientific research mission and promote the responsible development and evaluation of AI tools.
$222,703 spent$37,893 earned by the program27% of program spendingmisc program expenses
$22,057 spent3% of program spending
The 4 programs described on its FY2024 Form 990, listed largest first by expense. Program spending in total: $810,587.
The organization over time
Each line starts at 100 in 2024, so what you read is the shape rather than the size: 150 means half as much again as 2024, 50 means half. The number beside each label in the key is where it ended. The shaded band is where the middle 50% of its peers' revenue would sit, given their growth.
Balance sheet
Total assets and total liabilities at each year end, in dollars. The largest one-year move in total assets was 2024 to 2025, from $127k to $1.4M (+966%).
How it's funded, over time
Each bar is one year's revenue split into where it came from, and every bar is the same height — these are shares, not amounts, so a year that raised twice as much looks the same size. Hover a bar for the split.
98% of Active Site Research Inc’s revenue is contributions — more reliant on donations than three-quarters of its peers (51% for the typical peer).
Surplus & reserves
Operating surplus or deficit each year, and months of liquidity in hand. 0 of the last 2 reported years ran a deficit.
reserve
Leadership and staff
The officers, directors, trustees and key employees listed on each return. Joined and no longer listed compare each filing with the year before, matching people by surname and first initial; a year after a gap, or a roster under three people, has no comparison.
Board chair
Ales Flidr
Chairman
As listed on its FY2025 Form 990.
Who funds it, year by year
Grant support over time, funder by funder — shade shows the grant size each year.
3 of 4 of your funders are donor-advised or pass-through sponsors (tagged DAF) — 71% of grant dollars received. That money is really individual donors directing a sponsor; the institutions to cultivate are the non-DAF funders.
From the IRS filings of Active Site Research Inc’s funders (the co-funder graph). Association, not causation. Trends are read to FY2023, the last fiscal year that has finished arriving. FY2024–FY2026 are still being filed and are shown unshaded; they do not move any figure on this page.
How concentrated its funding is
Active Site Research Inc leans on a few funders — its largest provides 36% of grant income and the top three 94%; half comes from just 2 funders.
the vertical line marks half of all grant income — 2 funders to its left
100% of the income these shares are computed over arrives through pass-through sponsors or from payers whose filings do not say what kind of payment it is. Concentration is still measured over all of it, because the money is real; what it does not support is a claim about how many institutions have chosen to fund Active Site Research Inc.
“Effective funders” = inverse Herfindahl index (1 / Σ shareᵢ²) — the number of equal-sized funders that would give the same concentration. Trends are read to FY2023, the last fiscal year that has finished arriving. FY2024–FY2026 are still being filed and are shown unshaded; they do not move any figure on this page.
Where its funders are
71% of Active Site Research Inc's grant income arrives through donor-advised or pass-through sponsors, whose addresses record where the money is held rather than where the donor is. Of the $97k that is directly attributable, 100% of it comes from funders outside Massachusetts, across 1 state.
Funder states come from each funder’s own filing. $240k arriving through sponsors registered in 3 states is excluded from the map and the split above: a sponsor holds money on a donor’s behalf, so its registered address would place those dollars somewhere no donor need ever have been. Trends are read to FY2023, the last fiscal year that has finished arriving. FY2024–FY2026 are still being filed and are shown unshaded; they do not move any figure on this page.
Against its field
Active Site Research Inc runs a healthier operating margin than three-quarters of the 5,002 health nonprofits its size.
this organization peer median middle 50% of peers· 5,002 health nonprofits $1M–$10M, FY2025
Organizations like Active Site Research Inc
Organizations whose mission and program text most resemble this one, by semantic similarity over every organization in the US filings — the closest peers, and often the clearest route to shared or prospective funders.
In Massachusetts
Nationally
Read directly from this organization’s own Form 990, as neutral context.
Where the money goes
77% of spending goes to programs.
Governance
Public support
0%
Share of support from the public (Schedule A) — the basis for its public-charity status.
Footprint & structure
Files a return copy in 3 states
Screen this organization
A dated, signed PDF of the compliance screen for Active Site Research Inc: IRS status (Business Master File, Publication 78, auto-revocation), the OFAC sanctions lists, the Internal Revenue Bulletin, and California registration, with the Rev. Proc. 2018-32 §8.01 reliance elements stated element by element. Generated from the current files at the moment you download it.
Screens are triage, not determinations; a source that cannot be read reports not screened, never clear. Screen this nonprofit · How the screen works · on the API as GET /api/screening/{ein}?format=pdf
Questions and answers
- Who funds Active Site Research Inc?
- Active Site Research Inc (Massachusetts) receives grants from 4 organizations whose IRS filings report $337,000 to it, the largest being Silicon Valley Community Foundation ($120,000). 0 of them have funded it in more than one year, and 71% of the money arrives through donor-advised or pass-through sponsors rather than from an institution directly.
- How many funders does Active Site Research Inc have?
- IRS filings report 4 organizations giving $337,000 in grants to Active Site Research Inc.
- Who is the largest funder of Active Site Research Inc?
- Silicon Valley Community Foundation is the largest funder on record, with $120,000 in grants. The full list of funders is on this page.
- How can an organization like Active Site Research Inc find more funders?
- Start with the funders already giving here, then look at the foundations that back similar organizations in Massachusetts. The funding by cause and by state pages list the largest funders for a given area and how to approach them.
These figures are read directly from IRS Form 990 / 990-PF e-file XML: this organization’s own return for FY2025 (financials across 2024–2025), and the filings of 4 funders that report grants to it. “On record” means captured in the filings we have parsed — a funder that does not e-file, or whose grant detail is not itemized, will not appear. Filings run roughly 12–24 months behind. Trends on this page end at FY2023, the last fiscal year that has finished arriving; later years are shown and marked, and move no figure. Data on this page was exported October 22, 2026. What this page cannot tell you · view filing