Skip to content
National Pku Alliance Inc at a glanceMostly funded, not a grantmaker: see who funds it →

· Public charity

National Pku Alliance Inc

Our mission is to improve the lives of individuals with pku, pursue a cure by expanding research and provide education and support to individuals living with pku and their caregivers.

$459k
Granted FY2025still arriving
8
Grants FY2025still arriving
6
States reached
$169k
Largest
01What it fundsRead
02The needRead
03Its granteesRead
04Its fieldRead
01What it funds
01100% classified

What it funded, over time

Every grant placed by its stated purpose and the recipient’s mission, by year, FY2017 to 2025.

Health$2.4MEducation$845kScience & Tech$316kPhilanthropy$156kHuman Services$25k
02FY2025 · 8 grants

Where the money goes

Grants by size, and the largest recipients.

How this is measured
The 8 grants below total $404,367, the rows itemized in this filing. The $459,015 headline is the total grant expense on the return; the other $54,648 is giving the schedule does not break out (grants under the $5,000 itemization floor, grants to individuals, grants on other schedules). Every figure below describes the itemized rows only.

By grant size · FY2025

  • Under $10k3 grants · $24k
  • $10k–50k1 grant · $10k
  • $50k–250k4 grants · $371k
$50,000
Median grant
6
States reached
$6.2M
Total assets
Largest grants
RecipientAmount
OREGON HEALTH & SCIENCE$169,344
UNIVERSITY OF CALIFORNIA SAN DIEGO$80,000
BOSTON CHILDREN'S HOSPITAL$71,394
EMORY UNIVERSITY SCHOOL OF MEDICINE$50,000
MARYLAND ALLIANCE OF PKU FAMILIES INC$10,098
PKU ORGANIZATION OF ILLINOIS$8,531
GEORGIA PKU CONNECT INC$7,500
CALIFORNIA COALITION FOR PKU AND ALLIED DISORDERS$7,500
02The need
03

Does the money reach high-need areas?

Each grant placed by the hardship in its grantee’s ZIP, against the area’s typical level.

show:

Dollar for dollar, its grants (FY17–25) land where the poverty rate runs at 13%, against an area that typically sits at 10%. 97% of its dollars go to grantees based in above-average-need neighborhoods. Most of its grants land in higher-need ZIPs.

area typical 10%BOSTON CHILDREN'S HOSPITAL: $71k → 16%UNIVERSITY OF PITTSBURGH: $95k → 11%FOX CHASE CANCER CENTER: $40k → 22%CALIFORNIA COALITION FOR PKU AND ALLIED DISORDERS: $10k → 8%UNIVERSITY OF CALIFORNIA SAN DIEGO: $80k → 11%UNIVERSITY OF SOUTHERN CALIFORNIA: $40k → 14%MID-ATLANTIC CONNECTION FOR PKU & ALLIED DISORDERS: $12k → 13%UNIVERSITY OF NORTHER TEXAS HEALTH SCIENCE CENTER: $55k → 11%CLEMSON UNIVERSITY: $29k → 16%WASHINGTON UNIVERSITY ST LOUIS: $130k → 21%OREGON HEALTH AND SCIENCE UNIVERSITY: $40k → 12%INTERMOUNTAIN PKU AND ALLIED DISORDERS ASSOCIATION: $11k → 8%EMORY UNIVERSITY SCHOOL OF MEDICINE: $50k → 14%OHIO STATE UNIVERSITY RESEARCH FOUNDATION: $40k → 15%THE UNIVERSITY OF CHICAGO: $55k → 14%MARYLAND ALLIANCE OF PKU FAMILIES INC: $10k → 6%CHILDREN'S RESEARCH INSTITUTE: $40k → 8%MARYLAND ALLIANCE OF PKU FAMILIES INC: $9k → 11%BOSTON'S CHILDREN HOSPITAL: $59k → 16%UNIVERSITY OF PITTSBURGH: $55k → 11%FOX CHASE CANCER CENTER: $40k → 22%CALIFORNIA COALITION FOR PKU AND ALLIED DISORDERS: $8k → 8%UNIVERSITY OF CALIFORNIA SAN DIEGO: $55k → 11%UNIVERSITY OF SOUTHERN CALIFORNIA: $20k → 14%UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER: $55k → 11%WASHINGTON UNIVERSITY ST LOUIS: $130k → 21%OREGON HEALTH AND SCIENCE UNIVERSITY: $306k → 12%THE UNIVERSITY OF CHICAGO: $55k → 14%MARYLAND ALLIANCE OF PKU FAMILIES INC: $10k → 6%MARYLAND ALLIANCE OF PKU FAMILIES INC: $7k → 11%UNIVERSITY OF PITTSBURGH: $55k → 11%UNIVERSITY OF PENNSYLVANIA: $50k → 22%CALIFORNIA COALITION FOR PKU AND ALLIED DISORDERS: $6k → 8%OREGON HEALTH AND SCIENCE UNIVERSITY: $249k → 12%MARYLAND ALLIANCE OF PKU FAMILIES INC: $8k → 6%UNIVERSITY OF PITTSBURGH: $70k → 11%OREGON HEALTH AND SCIENCE UNIVERSITY: $241k → 12%OREGON HEALTH AND SCIENCE UNIVERSITY: $190k → 12%OREGON HEALTH AND SCIENCE UNIVERSITY: $183k → 12%OREGON HEALTH AND SCIENCE UNIVERSITY: $180k → 12%OREGON HEALTH & SCIENCE: $169k → 12%OREGON HEALTH AND SCIENCE UNIVERSITY: $159k → 12%0%20%40%50%more need →
grant to an above-average-need area below average· circle size = grant amount
How this is measured
Matched: human-services grants are those whose grantee’s IRS cause code is Human Services. Placed by people below the poverty line in the grantee’s ZIP, averaged from the tracts in that ZIP.

Which US states its grants reach

IL
NY
MA
OR
OH
PA
CA
UT
MO
MD
SC
GA
TX

Grants abroad, by region: $54k on the FY2025 return

Schedule F, as filed: 1 region. The IRS asks for region and purpose, not the recipient, so no country or grantee can be named here.

Europe (including Iceland and Greenland)$54k · 100% · 1 grant

Stated purpose: AI4PKU STUDY: ARTIFICIAL INTELLIGENCE FOR PKU

How this is measured
US grants placed by each grantee’s ZIP, which can differ from where services are delivered. Need from public data (U.S. Census/ACS, CDC PLACES, Eviction Lab, USDA), shown as context about the area, never attributed to the funder’s giving. Grants abroad on Schedule F are filed by region, purpose and amount with no recipient name, so they are shown by region and cannot be placed on the country map or matched to a grantee.
03Its grantees
repeat funding

Who it funds again

Organizations funded in more than one year, against those funded once.

80%of every dollar goes to organizations it has funded before.
$2.4M · 10 repeat orgs$591k to everyone else

Grantees it renews have grown median revenue +44% since the first grant, against -94% for those funded once.

10 repeat relationships: 4 still active in FY2025, 6 since wound down; 3 grantees were first funded in FY2025 (too recent to call).

How the two cohorts compare

Re-uppedFunded once

Organizations

10
9

Total granted

$2.4M
$452k

Median revenue growth · since first grant

+44%
-94%

Still filing today

50%
0%

New vs renewed · share of each year

In FY2025, 41% of grant dollars renewed an existing relationship; $139k went to new ones.

50%100%’17’18’19’20’21’22’23’24’25
RenewedFirst-time

Where new relationships form · theme of each grantee’s first grant

’17’18’19’20’21’22’23’24’25
EducationHealthOther
How this is measured
First-time means a grantee’s first year in the filing window; renewed means funded in an earlier year too. The renewed share climbs naturally as a portfolio matures, so the signal is a year that bucks it (a wave of new grantees). The earliest year is left-censored: relationships that predate the data read as new. Theme is the grantee’s IRS cause.

Backed again, and grew

  • UNIVERSITY OF PITTSBURGH
    4× · 2017–2021 · $274k · revenue +44%
  • WASHINGTON UNIVERSITY
    2× · 2019–2020 · $261k · revenue +44%
  • CH
    Children's Hospital Corporation
    3× · 2017–2025 · $260k · revenue +91%

Funded once

  • CO
    CURATORS OF THE UNIVERSITY OF MISSOURI SPECIAL TR
    one grant, 2023 · $156k
  • UO
    UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FT WORTH HEALTH SYSTEMS
    one grant, 2018 · $55k
  • UO
    UNIVERSITY OF NORTH TEXAS
    one grant, 2017 · $55k
How this is measured

Repeat means funded in two or more distinct years. Growth and survival are read from each grantee’s own subsequent IRS filings.

04Its field

Closest unfunded matches

The nonprofits that most resemble its grantees but are not funded by it, scored along the direction from the rest of the field toward the portfolio. A resemblance in what they say they do, not a recommendation.

1
New York University

Nyu is a private university with approximately 60,000 matriculating students in 20 schools and institutes. nyu's primary missions are education, research and scholarship, and patient care.

Education
2
Thomas Jefferson University

Thomas jefferson university ("tju") is a comprehensive university with preeminence in transdisciplinary, experiential professional education, research and discovery, delivering exceptional value for the 21st century students with…

Education
3
Truman Medical Center Incorporated

University health is an academic health center providing accessible, state-of-the-art quality healthcare to our community regardless of the ability to pay.

Health
4
Rush University Medical Center

The mission of Rush is to improve the health of the individuals and diverse communities we serve through the integration of outstanding patient care, education, research and community partnerships.

Health
5
University of Chicago Medical Center

Our mission at the university of chicago medicine is to provide superior health care through rigorous research, innovative education, and comprehensive care and healing. in partnership with our colleagues, we pursue life-changing…

Health
6
Fred Hutchinson Cancer Center

Fred hutch cancer center ("fred hutch") unites innovative research and compassionate care to prevent and eliminate cancer and infectious disease. continued on schedule o

Health
7
University of Minnesota Physicians

University of minnesota physicians serves as the integrated group practice for the university of minnesota medical school full-time faculty to provide the highest quality healthcare to patients and their families.university of minnesota…

Health
8
The Johns Hopkins Hospital

For more than 125 years, the mission of the johns hopkins hospital has been to lead the world in the diagnosis and treatment of disease and to train tomorrow's great physicians, nurses and scientists. above all, we aim to provide the…

Health
9
Drexel University

Drexel university fulfills its founder's vision of preparing each new generation of students for productive professional and civic lives while also focusing its collective expertise on solving society's greatest problems. drexel is an…

Education
10
University of Miami

See Form 990, Part I, Line 1, Description of Organization Mission.

Education
11
Temple University Hospital Inc

See Schedule OOur mission is to support Temple University and its Health Sciences Center academic programs by providing the clinical environment and service to support the highest quality teaching and training programs for health care…

Health
12
Memorial Sloan-Kettering Cancer Center

Leadership in the prevention, treatment, and cure of cancer through excellence, vision and cost effectiveness in patient care, outreach programs, research, and education.

Health
How this is measured
The grantee most central to the portfolio’s shape is University of Chicago; the most unlike its peers is Mid-Atlantic Connection for Pku Allied Disorder Inc. Resemblance is measured on each organization’s own IRS 990 mission text; it reflects how work is described, not its quality or impact.
04the grantee network

10 grantees tracked through their own filings, 2017–2025.

Each grant beside the grantee’s revenue from every source, year by year.

How this is measured

Counted here: distinct organizations funded across 2017 to 2025, not grant rows in a single year, so this will not match the grant count on the cover. 10 of the 24 grantees resolved in that span have returns of their own we could reconcile.

Each grantee is resolved to its own IRS returns. Association, dated; never a causal claim.

1
Load-bearing (≥25% of a budget)
1
Early backer (in before they grew)
9/10
Grantees still filing
8/10
Grew since first funded

Where the money sits, by cause and then by grantee

OREGON HEALTH & SCIENCE UNIVERSITY: $1,109,084 · OtherOREGON HEALTH & SCIENCE UNIVERSITYCURATORS OF THE UNIVERSITY OF MISSOURI: $207,005 · OtherCURATORS OF THE UNIVERSITY OF MISSOURICURATORS OF THE UNIVERSITY OF MISSOURI SPECIAL TR: $155,652 · OtherCURATORS OF THE UNIVERSITY OF MISSOURI SPECIAL TRUniversity of California San Diego: $80,000 · Other+10 more: $321,663 · Other+10 moreTRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA: $658,358 · EducationTRUSTEES OF THE UNIVERSITY OF PENNSYLVANIAUNIVERSITY OF PITTSBURGH: $274,127 · EducationUNIVERSITY OF PITTSBURGHWASHINGTON UNIVERSITY: $260,920 · EducationWASHINGTON UNIVERSITYUniversity of Chicago: $110,301 · EducationUniversity of ChicagoUNIVERSITY OF SOUTHERN CALIFORNIA: $60,000 · EducationEmory University: $50,000 · Education+1 more: $12,000 · EducationChildren's Hospital Corporation: $260,422 · HealthChildren's H…The Institute For Cancer Research: $80,000 · HealthThe Institut…UNIVERSITY OF NORTH TEXAS HEALTH SCIENCE CENTER AT FT WORTH HEALTH SYSTEMS: $55,000 · HealthUNIVERSITY O…
Other$1,873,404Education$1,425,706Health$395,422

Each grantee by its size and the funder’s share of it; top left is load-bearing

25%50%75%100%$100k$1.0M$10M$100Mgrantee revenue →↑ funder's share of their budgetTRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA: $658,358 over 3y, 0.0% of budgetUNIVERSITY OF PITTSBURGH: $274,127 over 4y, 0.0% of budgetWASHINGTON UNIVERSITY: $260,920 over 2y, 0.0% of budgetChildren's Hospital Corporation: $260,422 over 3y, 0.0% of budgetUniversity of Chicago: $110,301 over 2y, 0.0% of budgetThe Institute For Cancer Research: $80,000 over 2y, 0.1% of budgetUNIVERSITY OF SOUTHERN CALIFORNIA: $60,000 over 2y, 0.0% of budgetMID-ATLANTIC CONNECTION FOR PKU ALLIED DISORDER INC: $12,000 over 1y, 36% of budgetPKU ORGANIZATION OF ILLINOIS: $8,531 over 1y, 17% of budget
Grantee by grantee: a decade per organization, before and after funding

A decade per grantee: revenue shaded, grants as bars, all rows on one timeline.

  • Who funds TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ↗
  • Who funds UNIVERSITY OF PITTSBURGH ↗
  • Who funds WASHINGTON UNIVERSITY ↗
  • Who funds Children's Hospital Corporation ↗
  • Who funds University of Chicago ↗
  • Who funds The Institute For Cancer Research ↗
  • Who funds UNIVERSITY OF SOUTHERN CALIFORNIA ↗
  • Who funds Emory University ↗
  • Who funds MID-ATLANTIC CONNECTION FOR PKU ALLIED DISORDER INC ↗
  • Who funds PKU ORGANIZATION OF ILLINOIS ↗

Co-funders

Grantmakers whose grantees overlap with this funder’s far more than size alone predicts. Closer means stronger alignment; arcs show where they also fund each other. Here they form a set of overlaps that mostly run through this funder rather than between each other.

Amazonsmile Foundation
Amazonsmile FoundationWA2× affinity7 shared granteesties to 0 of 0Hover any node to trace its alignments.Compare side by side →

Open a dossier: Amazonsmile Foundation

How this is measured
Affinity is a Gamma-Poisson posterior co-funding rate, re-centered on the typical rate, so thin evidence shrinks toward no signal. Overlap is association, not proof of shared intent.

How much its grantees rely on government

Each dot is one organization National Pku Alliance Inc funds: left to right is the share of its income from government, bottom to top the share from National Pku Alliance Inc. Bigger dots raise more.

2024
’20’21’22’23’24’25
no gov · 00%0%1%3%5%funder's share of their income ↑0%10%20%30%40%share of the org’s income from government →median 10%
  • Children's Hospital Corporation: 10% of income from government
no gov moneyreceives it· size = income
0get no government money at all
0rely on government for over half their income
⤢ axis zoomed · 0–40%
typical government reliance, FY20–25
How this is measured
Government income is each org’s traced federal awards (USASpending grants and contracts) plus state payments (open checkbooks) as a share of its total revenue (IRS Form 990); the self-reported government-grant line (990 line 1e) is carried for cross-check: a grantee that reports government grants we could not trace to a source is left off the chart rather than shown as receiving none. An association, not a claim that a grant caused the public funding. Coverage is precision-first, a floor rather than a census; state records exist for 9 states, so a grantee outside them shows no state figure (dimmed) rather than a false zero. Federal award amounts are obligations, which can span years, so a single-year share is indicative. 990 filings lag 12 to 24 months.

On method. Every financial figure here is read from IRS e-file XML, the funder’s own 990/990-PF, and from the multi-year returns of the 24 grantees we resolved, each linked to its source. Grantee outcomes are each organization’s own program-service reporting (Form 990, Part III), read as association with funding, never as caused by it. Low-confidence name matches are suppressed rather than guessed. How we build these →

How this is measured
Each figure carries one of six labels. Filed is what the funder reported on its return. Official is another government record about an organization, such as a federal award or a charity register, joined by name where no shared identifier exists. Resolved is an identity we worked out where the filing named a recipient without an EIN, kept only above a measured confidence threshold. Computed is arithmetic over those, like themes, portfolio clusters and co-funder strength. Context is a statistic about a place rather than about an organization, which is what the need overlay is: it describes the area a grantee’s address sits in, not where its work lands. Inferred is drawn by a model from text, like the partnerships read out of public news and organization websites. Each is labeled where it appears.

Generated from the IRS Form 990 e-file return for fiscal year 2025, released 2025. Filings run roughly 12 to 24 months behind; figures are dated accordingly.

Source object · view filing

Play a game based on National Pku Alliance’s filings →

More from the funding graph

The unnamed billions
grants reported with no recipient in the public record
The regranting layer
51% of grant dollars land in the regranting layer
The DAF merry-go-round
$9.7B circulates between donor-advised funds
The endowment market
who holds foundation money, and what just moved
The camps
funders cluster by geography, not ideology
By state
where grant money is based, and what stays home