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International Rett Syndrome Foundation at a glanceMostly funded, not a grantmaker: see who funds it →

· Public charity

International Rett Syndrome Foundation

To accelerate full spectrum research to cure rett syndrome and empower families with information, knowledge, and connectivity.

$1.6M
Granted FY2025still arriving
10
Grants FY2025still arriving
9
States reached
$206k
Largest
01What it fundsRead
02The needRead
03Its granteesRead
04Its fieldRead
05Through PlinthRead
01What it funds
01100% classified

What it funded, over time

Every grant placed by its stated purpose and the recipient’s mission, by year, FY2017 to 2024.

Health$9.9M
02FY2025 · 10 grants

Where the money goes

Grants by size, and the largest recipients.

How this is measured
The 10 grants below total $1,377,096, the rows itemized in this filing. The $1,611,176 headline is the total grant expense on the return; the other $234,080 is giving the schedule does not break out (grants under the $5,000 itemization floor, grants to individuals, grants on other schedules). Every figure below describes the itemized rows only.
$150,000
Median grant
9
States reached
$4.7M
Total assets
Largest grants
RecipientAmount
VANDERBILT UNIVERSITY$206,250
REGENTS OF THE UNIVERSITY OF CALIFORNIA$199,998
PRESIDENT & FELLOWS OF HARVARD COLLEGE$150,000
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA$150,000
THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL$150,000
THE UNIVERSITY OF TEXAS AT DALLAS$146,271
SYRACUSE UNIVERSITY$137,376
UNIVERSITY OF VIRGINIA RECTOR & VISITORS$100,000
UNIVERSITY OF NORTH CAROLINA - CHAPEL HILL$83,466
THE GEORGE WASHINGTON UNIVERSITY$53,735
02The need
03

Does the money reach high-need areas?

Each grant placed by the hardship in its grantee’s ZIP, against the area’s typical level.

show:

Dollar for dollar, its grants (FY17–25) land where the poverty rate runs at 13%, against an area that typically sits at 11%. 63% of its dollars go to grantees based in above-average-need neighborhoods. Most of its grants land in higher-need ZIPs.

area typical 11%Children's Hospital Boston: $150k → 16%The Regents of the University of California US San Diego: $150k → 10%The Regents of University of California: $150k → 14%Psychogenics Inc: $450k → 9%Syracuse University: $150k → 14%The Rockefeller University: $120k → 17%Albert Einstein College of Medicine: $150k → 28%THE UNIVERSITY OF TEXAS AT DALLAS: $146k → 14%Baylor College of Medicine: $250k → 16%Greenwood Genetic Center: $125k → 18%University of Wisconsin-Madison: $300k → 10%Vanderbilt University: $425k → 14%North Carolina State University: $121k → 8%Duke University: $150k → 11%The University of North Carolina at Chapel Hill: $100k → 13%North Carolina State University: $150k → 20%University of Colorado: $150k → 12%The Regents of the University of Colorado: $138k → 12%Loyola University Chicago: $150k → 14%University of Virginia Rector & Visitors: $100k → 8%Boston Children's Hospital: $150k → 16%THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA: $150k → 22%The Regents of the University of California US San Diego: $100k → 10%Psychogenics Inc: $300k → 9%SYRACUSE UNIVERSITY: $137k → 14%The Rockefeller University: $120k → 17%University of Texas Southwestern: $138k → 14%Baylor College of Medicine: $100k → 16%Greenwood Genetic Center: $125k → 18%University of Wisconsin: $300k → 10%Vanderbilt University: $175k → 14%University of North Carolina at Chapel Hill: $100k → 13%North Carolina State University: $121k → 20%The Regents of University of Colorado: $138k → 12%Loyola Univeristy Chicago: $150k → 14%UNIVERSITY OF VIRGINIA RECTOR & VISITORS: $100k → 8%The University of Texas Southwestern Medical Center: $138k → 14%University of Wisconsin at Madison: $150k → 10%VANDERBILT UNIVERSITY: $206k → 14%The General Hospital Corporation dba Massachusetts General Hospital: $300k → 8%Massachusetts General Hospital: $150k → 16%University of California San Diego: $142k → 11%Vanderbilt University: $138k → 14%THE GENERAL HOSPITAL CORPORATION DBA MASSACHUSETTS GENERAL HOSPITAL: $150k → 8%Massachusetts General Hospital: $600k → 16%University of California San Diego: $150k → 11%University of California San Diego: $150k → 11%PRESIDENT & FELLOWS OF HARVARD COLLEGE: $150k → 8%0%20%40%50%more need →
grant to an above-average-need area below average· circle size = grant amount
How this is measured
Matched: human-services grants are those whose grantee’s IRS cause code is Human Services. Placed by people below the poverty line in the grantee’s ZIP, averaged from the tracts in that ZIP.

Which US states its grants reach

IL
WI
NY
MA
OH
PA
NJ
CA
CO
VA
TN
NC
SC
DC
AL
TX
FL

Grants abroad, by region: $234k on the FY2025 return

Schedule F, as filed: 2 regions. The IRS asks for region and purpose, not the recipient, so no country or grantee can be named here.

Europe (including Iceland and Greenland)$184k · 79% · 2 grants

Stated purpose: RESEARCH

North America (Canada and Mexico)$50k · 21% · 1 grant

Stated purpose: RESEARCH

How this is measured
US grants placed by each grantee’s ZIP, which can differ from where services are delivered. Need from public data (U.S. Census/ACS, CDC PLACES, Eviction Lab, USDA), shown as context about the area, never attributed to the funder’s giving. Grants abroad on Schedule F are filed by region, purpose and amount with no recipient name, so they are shown by region and cannot be placed on the country map or matched to a grantee.
03Its grantees
repeat funding

Who it funds again

Organizations funded in more than one year, against those funded once.

81%of every dollar goes to organizations it has funded before.
$8.8M · 21 repeat orgs$2.0M to everyone else

Grantees it renews have grown median revenue +40% since the first grant, against +39% for those funded once.

21 repeat relationships: 6 still active in FY2025, 15 since wound down; 2 grantees were first funded in FY2025 (too recent to call).

How the two cohorts compare

Re-uppedFunded once

Organizations

21
16

Total granted

$8.8M
$1.8M

Median revenue growth · since first grant

+40%
+39%

Still filing today

48%
38%

New vs renewed · share of each year

In FY2025, 81% of grant dollars renewed an existing relationship; $200k went to new ones.

50%100%’17’18’19’20’21’22’23’24’25
RenewedFirst-time

Where new relationships form · theme of each grantee’s first grant

’17’18’19’20’21’22’23’24’25
EducationHealthOther
How this is measured
First-time means a grantee’s first year in the filing window; renewed means funded in an earlier year too. The renewed share climbs naturally as a portfolio matures, so the signal is a year that bucks it (a wave of new grantees). The earliest year is left-censored: relationships that predate the data read as new. Theme is the grantee’s IRS cause.

Backed again, and grew

  • Vanderbilt University
    7× · 2017–2025 · $1.3M · revenue +74%
  • BC
    Baylor College of Medicine
    2× · 2019–2022 · $350k · revenue +47%
  • CH
    Children's Hospital Corporation
    2× · 2017–2021 · $300k · revenue +91%

Funded once

  • UO
    University of Wisconsin
    one grant, 2022 · $300k
  • RU
    REGENTS UNIV OF CALIFORNIA
    one grant, 2021 · $150k
  • UO
    UNIVERSITY OF ALABAMA AT BIRMINGHAM
    one grant, 2017 · $150k
How this is measured

Repeat means funded in two or more distinct years. Growth and survival are read from each grantee’s own subsequent IRS filings.

04Its field

Closest unfunded matches

The nonprofits that most resemble its grantees but are not funded by it, scored along the direction from the rest of the field toward the portfolio. A resemblance in what they say they do, not a recommendation.

1
New York University

Nyu is a private university with approximately 60,000 matriculating students in 20 schools and institutes. nyu's primary missions are education, research and scholarship, and patient care.

Education
2
Lehigh University

The university's goal in the coming decade is to advance learning through the integration of teaching, research and service to others. the core of this goal is to prepare graduates to engage with the world and lead lives of meaning. to do…

Education
3
University of Miami

See Form 990, Part I, Line 1, Description of Organization Mission.

Education
4
University of Southern California

The central mission of the university of southern california is the development of human beings and society as a whole through the cultivation and enrichment of the human mind and spirit. the principal means by which our mission is…

Education
5
Albany College of Pharmacy and Health Sciences

We educate the next generation of leaders to improve the health of our society.

Education
6
Cornell University

Education, research, medical services and other public services.

Education
7
William Marsh Rice University

As a leading research university with a distinctive commitment to undergraduate education, Rice University aspires to path breaking research, unsurpassed teaching, and contributions to the betterment of our world. It seeks to fulfill this…

Education
8
Drexel University

Drexel university fulfills its founder's vision of preparing each new generation of students for productive professional and civic lives while also focusing its collective expertise on solving society's greatest problems. drexel is an…

Education
9
The Trustees of Princeton University

Research, education and general - princeton university is a private not-for-profit, non-sectarian institution of higher learning with approximately 5,700 undergraduate and 3,300 graduate students. 2,500 students graduated in the 2024-2025…

Education
10
Trustees of Dartmouth College

Dartmouth College educates the most promising students and prepares them for a lifetime of learning and of responsible leadership, through a faculty dedicated to teaching and the creation of knowledge.

Education
11
Trustees of Boston University

Organization's mission: boston university is an international, comprehensive, private research university, committed to educating students to be reflective, resourceful individuals ready to live, adapt, and lead in an interconnected world.…

—
12
Trustees of Tufts College

Education and Research

Education
How this is measured
The grantee most central to the portfolio’s shape is The George Washington University; the most unlike its peers is Sanford Burnham Prebys Medical Discovery Institute. Resemblance is measured on each organization’s own IRS 990 mission text; it reflects how work is described, not its quality or impact.
04the grantee network

21 grantees tracked through their own filings, 2017–2025.

Each grant beside the grantee’s revenue from every source, year by year.

How this is measured

Counted here: distinct organizations funded across 2017 to 2025, not grant rows in a single year, so this will not match the grant count on the cover. 21 of the 42 grantees resolved in that span have returns of their own we could reconcile.

Each grantee is resolved to its own IRS returns. Association, dated; never a causal claim.

0
Load-bearing (≥25% of a budget)
0
Early backer (in before they grew)
20/21
Grantees still filing
16/21
Grew since first funded

Where the money sits, by cause and then by grantee

MASS GENERAL BRIGHAM INCORPORATED: $1,268,602 · OtherMASS GENERAL BRIGHAM INCORPORATEDPsychogenics Inc: $795,000 · OtherPsychogenics IncREGENTS OF THE UNIVERSITY OF COLORADO: $690,000 · OtherREGENTS OF THE UNIVERSITY OF COLORADOUniversity of Wisconsin Madison: $450,000 · OtherUniversity of Wisconsin MadisonREGENTS OF THE UNIVERSITY OF CALIFORNIA AT SAN DIEGO: $450,000 · OtherREGENTS OF THE UNIVERSITY OF CALIFORNIA AT SAN DIEGOREGENTS OF THE UNIVERSITY OF CALIFORNIA: $375,000 · OtherREGENTS OF THE UNIVERSITY OF CALIFORNIAUniversity of Wisconsin: $300,000 · OtherUNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL: $283,464 · OtherTHE UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTE: $275,000 · OtherNorth Carolina State University: $270,982 · OtherUNIVERSITY OF CALIFORNIA DAVIS: $256,248 · Other+13 more: $1,491,080 · Other+13 moreVanderbilt University: $1,335,461 · EducationVanderbilt UniversityBaylor College of Medicine: $350,000 · EducationBaylor College of MedicineLOYOLA UNIVERSITY OF CHICAGO: $300,000 · EducationLOYOLA UNIVERSITY OF CHICAGOSYRACUSE UNIVERSITY: $287,305 · EducationSYRACUSE UNIVERSITYTHE ROCKEFELLER UNIVERSITY: $240,000 · EducationTHE ROCKEFELLER UNIVERSITYTRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA: $225,000 · EducationTRUSTEES OF THE UNIVERSITY OF PENN…President and Fellows of Harvard College: $150,000 · EducationDUKE UNIVERSITY: $150,000 · EducationICAHN SCHOOL OF MEDICINE AT MOUNT SINAI: $149,996 · EducationYESHIVA UNIVERSITY: $149,912 · Education+2 more: $99,935 · EducationChildren's Hospital Corporation: $300,000 · HealthChildren'…GREENWOOD GENETIC CENTER INC: $250,000 · HealthGREENWOOD…SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE: $150,000 · HealthSANFORD B…WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH: $137,500 · HealthWHITEHEAD…CHILDREN'S HOSPITAL MEDICAL CENTER: $40,500 · HealthTHE CHILDREN'S HOSPITAL OF PHILADELPHIA: $40,100 · Health
Other$6,905,376Education$3,437,609Health$918,100

Each grantee by its size and the funder’s share of it; top left is load-bearing

25%50%75%100%$10M$100Mgrantee revenue →↑ funder's share of their budgetVanderbilt University: $1,335,461 over 7y, 0.0% of budgetBaylor College of Medicine: $350,000 over 2y, 0.0% of budgetChildren's Hospital Corporation: $300,000 over 2y, 0.0% of budgetLOYOLA UNIVERSITY OF CHICAGO: $300,000 over 2y, 0.0% of budgetSYRACUSE UNIVERSITY: $287,305 over 2y, 0.0% of budgetGREENWOOD GENETIC CENTER INC: $250,000 over 2y, 0.6% of budgetTHE ROCKEFELLER UNIVERSITY: $240,000 over 2y, 0.0% of budgetTRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA: $225,000 over 2y, 0.0% of budgetPresident and Fellows of Harvard College: $150,000 over 1y, 0.0% of budgetDUKE UNIVERSITY: $150,000 over 1y, 0.0% of budgetSANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE: $150,000 over 3y, 0.1% of budgetICAHN SCHOOL OF MEDICINE AT MOUNT SINAI: $149,996 over 3y, 0.0% of budgetYESHIVA UNIVERSITY: $149,912 over 1y, 0.1% of budgetUNIVERSITY OF SAN DIEGO: $142,406 over 1y, 0.0% of budgetWHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH: $137,500 over 3y, 0.1% of budgetMARYMOUNT UNIVERSITY: $75,000 over 1y, 0.1% of budgetEARLY SIGNAL FOUNDATION INC: $57,246 over 1y, 3.4% of budgetThe George Washington University: $53,735 over 1y, 0.0% of budgetMassachusetts Institute of Technology: $46,200 over 1y, 0.0% of budgetCHILDREN'S HOSPITAL MEDICAL CENTER: $40,500 over 1y, 0.0% of budgetTHE CHILDREN'S HOSPITAL OF PHILADELPHIA: $40,100 over 1y, 0.0% of budget
Grantee by grantee: a decade per organization, before and after funding

A decade per grantee: revenue shaded, grants as bars, all rows on one timeline.

  • Who funds Vanderbilt University ↗
  • Who funds Baylor College of Medicine ↗
  • Who funds Children's Hospital Corporation ↗
  • Who funds LOYOLA UNIVERSITY OF CHICAGO ↗
  • Who funds SYRACUSE UNIVERSITY ↗
  • Who funds GREENWOOD GENETIC CENTER INC ↗
  • Who funds THE ROCKEFELLER UNIVERSITY ↗
  • Who funds TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA ↗
  • Who funds President and Fellows of Harvard College ↗
  • Who funds DUKE UNIVERSITY ↗
  • Who funds SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE ↗
  • Who funds ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ↗
  • Who funds YESHIVA UNIVERSITY ↗
  • Who funds UNIVERSITY OF SAN DIEGO ↗
  • Who funds WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH ↗
  • Who funds MARYMOUNT UNIVERSITY ↗
  • Who funds EARLY SIGNAL FOUNDATION INC ↗
  • Who funds The George Washington University ↗
  • Who funds Massachusetts Institute of Technology ↗

Co-funders

Grantmakers whose grantees overlap with this funder’s far more than size alone predicts. Closer means stronger alignment; arcs show where they also fund each other. Here they form a tightly interlocked group: most of these funders back each other's grantees too.

Donor Advised Charita…Fidelity Investments …
Donor Advised Charitable Giving IncCA4.1× affinity4 shared granteesties to 1 of 1Hover any node to trace its alignments.Compare side by side →

Open a dossier: Donor Advised Charitable Giving Inc · Fidelity Investments Charitable Gift Fund

How this is measured
Affinity is a Gamma-Poisson posterior co-funding rate, re-centered on the typical rate, so thin evidence shrinks toward no signal. Overlap is association, not proof of shared intent.

How much its grantees rely on government

Each dot is one organization International Rett Syndrome Foundation funds: left to right is the share of its income from government, bottom to top the share from International Rett Syndrome Foundation. Bigger dots raise more.

2024
’20’21’22’23’24’25
no gov · 00%0%1%3%5%funder's share of their income ↑0%19%38%56%75%share of the org’s income from government →median 10%
  • Massachusetts Institute of Technology: 35% of income from government
  • Children's Hospital Corporation: 10% of income from government
  • Whitehead Institute for Biomedical Research: 7% of income from government
no gov moneyreceives it· size = income
0get no government money at all
0rely on government for over half their income
⤢ axis zoomed · 0–75%
typical government reliance, FY20–25
How this is measured
Government income is each org’s traced federal awards (USASpending grants and contracts) plus state payments (open checkbooks) as a share of its total revenue (IRS Form 990); the self-reported government-grant line (990 line 1e) is carried for cross-check: a grantee that reports government grants we could not trace to a source is left off the chart rather than shown as receiving none. An association, not a claim that a grant caused the public funding. Coverage is precision-first, a floor rather than a census; state records exist for 9 states, so a grantee outside them shows no state figure (dimmed) rather than a false zero. Federal award amounts are obligations, which can span years, so a single-year share is indicative. 990 filings lag 12 to 24 months.
05Through Plinth

Warm introductions · Powered by PlinthPlus

How do I get to International Rett Syndrome Foundation?

Find your warmest path to International Rett Syndrome Foundation through trustees and officers whose names appear on both boards. Search for your organization and Plinth traces the shortest route it can evidence.

Each link is a name appearing on two organizations’ public IRS 990 filings, matched on that name and, where the filings support it, on location. A same-state match has geographic support, which is a second matching feature rather than confirmation that the two are one person; a cross-state one is the likeliest to be two people who share a name. Every hop shows its tier, low-confidence and distant paths are held back rather than guessed, and it is worth confirming the person before you use the introduction.

On method. Every financial figure here is read from IRS e-file XML, the funder’s own 990/990-PF, and from the multi-year returns of the 42 grantees we resolved, each linked to its source. Grantee outcomes are each organization’s own program-service reporting (Form 990, Part III), read as association with funding, never as caused by it. Low-confidence name matches are suppressed rather than guessed. How we build these →

How this is measured
Each figure carries one of six labels. Filed is what the funder reported on its return. Official is another government record about an organization, such as a federal award or a charity register, joined by name where no shared identifier exists. Resolved is an identity we worked out where the filing named a recipient without an EIN, kept only above a measured confidence threshold. Computed is arithmetic over those, like themes, portfolio clusters and co-funder strength. Context is a statistic about a place rather than about an organization, which is what the need overlay is: it describes the area a grantee’s address sits in, not where its work lands. Inferred is drawn by a model from text, like the partnerships read out of public news and organization websites. Each is labeled where it appears.

Generated from the IRS Form 990 e-file return for fiscal year 2025, released 2025. Filings run roughly 12 to 24 months behind; figures are dated accordingly.

Source object · view filing

Play a game based on International Rett Syndrome’s filings →

More from the funding graph

The unnamed billions
grants reported with no recipient in the public record
The regranting layer
51% of grant dollars land in the regranting layer
The DAF merry-go-round
$9.7B circulates between donor-advised funds
The endowment market
who holds foundation money, and what just moved
The camps
funders cluster by geography, not ideology
By state
where grant money is based, and what stays home